S-adenosylmethionine (AdoMet, SAM) is an essential metabolit...

created [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
dbId 179170
displayName S-adenosylmethionine (AdoMet, SAM) is an essential metabolit...
modified [InstanceEdit:5603083] Jassal, Bijay, 2014-06-27
schemaClass Summation
text S-adenosylmethionine (AdoMet, SAM) is an essential metabolite in all cells. AdoMet is a precursor in the synthesis of polyamines. Methionine adenosyltransferases (MAT) catalyse the only known AdoMet biosynthetic reaction from methionine (L-Met) and ATP. In mammalian tissues, three different forms of MAT (MAT I, MAT III and MAT II) have been identified that are the product of two different genes (MAT1A and MAT2A). MAT1A binds 1 K+ and 2 Mg2+ (or Co2+, not shown here) in tetrameric or dimeric form (Corrales et al. 2002, Mato et al. 1997).
Cite Us!