Reactome | TPMT transfers CH3 from AdoMet to 6MP

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TPMT transfers CH3 from AdoMet to 6MP Show undefined attributes

catalystActivity	[CatalystActivity:158629] thiopurine S-methyltransferase activity of TPMT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:158630] Jassal, B, 2005-02-03 14:13:47
dbId	158609
diseaseReaction	[FailedReaction:R-HSA-5603379] TPMT does not transfer CH3 from AdoMet to 6MP - Homo sapiens
displayName	TPMT transfers CH3 from AdoMet to 6MP
eventOf	[Pathway:R-HSA-156581] Methylation - Homo sapiens
followingEvent	[Reaction:R-HSA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Homo sapiens
input	[SimpleEntity:R-ALL-158619] 6MP [cytosol] [SimpleEntity:R-ALL-71284] AdoMet [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:158621] Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues. [LiteratureReference:158627] Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase [LiteratureReference:176025] The thiopurines: an update [LiteratureReference:176020] Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations [LiteratureReference:5618154] Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	TPMT transfers CH3 from AdoMet to 6MP 6-mercaptopurine can be S-methylated
orthologousEvent	[Reaction:R-BTA-158609] TPMT transfers CH3 from AdoMet to 6MP - Bos taurus [Reaction:R-GGA-158609] TPMT transfers CH3 from AdoMet to 6MP - Gallus gallus [Reaction:R-XTR-158609] TPMT transfers CH3 from AdoMet to 6MP - Xenopus tropicalis [Reaction:R-DRE-158609] TPMT transfers CH3 from AdoMet to 6MP - Danio rerio [Reaction:R-SSC-158609] TPMT transfers CH3 from AdoMet to 6MP - Sus scrofa [Reaction:R-CFA-158609] TPMT transfers CH3 from AdoMet to 6MP - Canis familiaris [Reaction:R-RNO-158609] TPMT transfers CH3 from AdoMet to 6MP - Rattus norvegicus [Reaction:R-MMU-158609] TPMT transfers CH3 from AdoMet to 6MP - Mus musculus
output	[SimpleEntity:R-ALL-158611] 6MMP [cytosol] [SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-76386] CYP1A2 S-demethylates 6MMP - Homo sapiens [Reaction:R-HSA-174391] MAT1A multimers transfer Ado from ATP to L-Met - Homo sapiens [Reaction:R-HSA-5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met - Homo sapiens
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-158609
summation	[Summation:176023] Methylation is the major biotransformation route of thiopuri...
updateTrackers	[UpdateTracker:9790604] Update Tracker - [Reaction:158609] TPMT transfers CH3 from AdoMet to 6MP - v33:[addOutput] [UpdateTracker:9786232] Update Tracker - [Reaction:158609] TPMT transfers CH3 from AdoMet to 6MP - v50:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790604] Update Tracker - [Reaction:158609] TPMT transfers CH3 from AdoMet to 6MP - v33:[addOutput] [UpdateTracker:9786232] Update Tracker - [Reaction:158609] TPMT transfers CH3 from AdoMet to 6MP - v50:[addLiteratureReference, modifyText]
(normalReaction)	[FailedReaction:R-HSA-5603379] TPMT does not transfer CH3 from AdoMet to 6MP
(hasEvent)	[Pathway:R-HSA-156581] Methylation
(precedingEvent)	[Reaction:R-HSA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy

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