Reactome | S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2

Schema > Reaction > Entries

S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 Show undefined attributes

authored	[InstanceEdit:351144] Gopinathrao, G, 2008-05-21 15:52:50
catalystActivity	[CatalystActivity:351211] adenosylmethionine decarboxylase activity of AMD1(1-67) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667651] RHEA:15982 [DatabaseIdentifier:9955567] RHEA:15982
dbId	351222
displayName	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2
edited	[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
eventOf	[Pathway:R-HSA-351202] Metabolism of polyamines - Homo sapiens
followingEvent	[Reaction:R-HSA-351215] Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine - Homo sapiens [Reaction:R-HSA-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Homo sapiens
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:353589] The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 S-adenosyl-L-methionine + H(+) => S-adenosyl 3-(methylsulfanyl)propylamine + CO2
orthologousEvent	[Reaction:R-SCE-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Saccharomyces cerevisiae [Reaction:R-SPO-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Schizosaccharomyces pombe [Reaction:R-DDI-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Dictyostelium discoideum [Reaction:R-CEL-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Caenorhabditis elegans [Reaction:R-DME-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Drosophila melanogaster [Reaction:R-GGA-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Gallus gallus [Reaction:R-XTR-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Xenopus tropicalis [Reaction:R-DRE-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Danio rerio [Reaction:R-SSC-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Sus scrofa [Reaction:R-BTA-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Bos taurus [Reaction:R-CFA-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Canis familiaris [Reaction:R-RNO-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Rattus norvegicus [Reaction:R-MMU-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Mus musculus
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-353113] dc-AdoMet [cytosol]
precedingEvent	[Reaction:R-HSA-174391] MAT1A multimers transfer Ado from ATP to L-Met - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-09-30
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:377465] D'Eustachio, P, 2008-06-12 14:43:38 [InstanceEdit:9974434] D'Eustachio, Peter, 2025-11-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-351222
summation	[Summation:353574] S-Adenosylmethionine decarboxylase belongs to a small class ...
updateTrackers	[UpdateTracker:9790807] Update Tracker - [Reaction:351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - v33:[addOutput] [UpdateTracker:9964611] Update Tracker - [Reaction:351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - v94:[removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9790807] Update Tracker - [Reaction:351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - v33:[addOutput] [UpdateTracker:9964611] Update Tracker - [Reaction:351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - v94:[removeInput]
(hasEvent)	[Pathway:R-HSA-351202] Metabolism of polyamines
(precedingEvent)	[Reaction:R-HSA-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine [Reaction:R-HSA-351215] Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine