Reactome | SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy

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SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy Show undefined attributes

authored	[InstanceEdit:8855061] D'Eustachio, Peter, 2016-01-30
catalystActivity	[CatalystActivity:8855063] S-adenosyl-L-methionine transmembrane transporter activity of SLC25A26 [mitochondrial inner membrane]
catalystActivityReference	[CatalystActivityReference:9643407] S-adenosyl-L-methionine transmembrane transporter activity of SLC25A26 [mitochondrial inner membrane] Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:8855061] D'Eustachio, Peter, 2016-01-30
crossReference	[DatabaseIdentifier:12667706] RHEA:75479
dbId	8855062
displayName	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy
edited	[InstanceEdit:8855061] D'Eustachio, Peter, 2016-01-30
eventOf	[Pathway:R-HSA-549127] SLC-mediated transport of organic cations - Homo sapiens
followingEvent	[Reaction:R-HSA-6793096] MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370 - Homo sapiens [Reaction:R-HSA-6793066] TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937 - Homo sapiens [Reaction:R-HSA-6793057] NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841 - Homo sapiens [Reaction:R-HSA-6793122] MRM1 methylates guanosine-1145 of 16S rRNA yielding 2'-O-methylguanosine-1145 - Homo sapiens [Reaction:R-HSA-6793127] MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine - Homo sapiens [Reaction:R-HSA-6787594] TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 - Homo sapiens [Reaction:R-HSA-6787525] TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58 - Homo sapiens [Reaction:R-HSA-6787591] TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 - Homo sapiens [Reaction:R-HSA-2162193] COQ3 methylates DHDB - Homo sapiens [Reaction:R-HSA-2162188] COQ5 methylates MDMQ10H2 - Homo sapiens [Reaction:R-HSA-2162186] COQ3 methylates DeMQ10H2 - Homo sapiens [Reaction:R-HSA-6793591] LIAS synthesizes lipoyl-GCSH - Homo sapiens
input	[SimpleEntity:R-ALL-2162252] AdoHcy [mitochondrial matrix] [SimpleEntity:R-ALL-71284] AdoMet [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8855055] Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution [LiteratureReference:8855039] Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy
orthologousEvent	[Reaction:R-MMU-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Mus musculus [Reaction:R-PFA-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Plasmodium falciparum [Reaction:R-SCE-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Saccharomyces cerevisiae [Reaction:R-SPO-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Schizosaccharomyces pombe [Reaction:R-CEL-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Caenorhabditis elegans [Reaction:R-DME-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Drosophila melanogaster [Reaction:R-GGA-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Gallus gallus [Reaction:R-XTR-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Xenopus tropicalis [Reaction:R-DRE-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Danio rerio [Reaction:R-SSC-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Sus scrofa [Reaction:R-BTA-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Bos taurus [Reaction:R-CFA-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Canis familiaris [Reaction:R-RNO-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Rattus norvegicus
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-2162265] AdoMet [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-174391] MAT1A multimers transfer Ado from ATP to L-Met - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855125] Jassal, Bijay, 2016-02-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8855062
summation	[Summation:8855060] SLC25A26 (S-adenosylmethionine mitochondrial carrier protein...

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[Pathway:R-HSA-549127] SLC-mediated transport of organic cations

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