Reactome | NNMT transfers CH3 from AdoMet to PY

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NNMT transfers CH3 from AdoMet to PY Show undefined attributes

catalystActivity	[CatalystActivity:175975] pyridine N-methyltransferase activity of NNMT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:175984] Jassal, B, 2006-02-27 14:53:40
crossReference	[DatabaseIdentifier:12667633] RHEA:16894
dbId	175987
displayName	NNMT transfers CH3 from AdoMet to PY
eventOf	[Pathway:R-HSA-156581] Methylation - Homo sapiens
followingEvent	[Reaction:R-HSA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Homo sapiens
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-175973] PY [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8984501] A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	NNMT transfers CH3 from AdoMet to PY Pyridine can be N-methylated
orthologousEvent	[Reaction:R-XTR-175987] NNMT transfers CH3 from AdoMet to PY - Xenopus tropicalis [Reaction:R-MMU-175987] NNMT transfers CH3 from AdoMet to PY - Mus musculus [Reaction:R-RNO-175987] NNMT transfers CH3 from AdoMet to PY - Rattus norvegicus [Reaction:R-CEL-175987] NNMT transfers CH3 from AdoMet to PY - Caenorhabditis elegans [Reaction:R-CFA-175987] NNMT transfers CH3 from AdoMet to PY - Canis familiaris [Reaction:R-DRE-175987] NNMT transfers CH3 from AdoMet to PY - Danio rerio [Reaction:R-SSC-175987] NNMT transfers CH3 from AdoMet to PY - Sus scrofa [Reaction:R-BTA-175987] NNMT transfers CH3 from AdoMet to PY - Bos taurus
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-175979] MP+ [cytosol]
precedingEvent	[Reaction:R-HSA-174391] MAT1A multimers transfer Ado from ATP to L-Met - Homo sapiens [Reaction:R-HSA-5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-175987
summation	[Summation:176089] Pyridine is a typical substrate for Nicotinamide N-methyltra...
updateTrackers	[UpdateTracker:9781188] Update Tracker - [Reaction:175987] NNMT transfers CH3 from AdoMet to PY - v61:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781188] Update Tracker - [Reaction:175987] NNMT transfers CH3 from AdoMet to PY - v61:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-156581] Methylation
(precedingEvent)	[Reaction:R-HSA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy

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