Reactome | viral dsRNA binds IFIH1:TKFC

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viral dsRNA binds IFIH1:TKFC Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:913723] Garapati, P V, 2010-07-19
dbId	913725
displayName	viral dsRNA binds IFIH1:TKFC
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Homo sapiens
followingEvent	[Reaction:R-HSA-9833393] N interacts with IFIH1 - Homo sapiens [Reaction:R-HSA-168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - Homo sapiens
input	[DefinedSet:R-NUL-9038422] IFIH1 ligand [cytosol] [Complex:R-HSA-918203] IFIH1:TKFC [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:913728] Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5 [LiteratureReference:918206] Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase [LiteratureReference:936495] Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
modified	[InstanceEdit:9835853] Shamovsky, Veronica, 2023-05-18
name	viral dsRNA binds IFIH1:TKFC viral dsRNA binds IFIH1:DAK dsRNA binds to MDA5
orthologousEvent	[Reaction:R-GGA-1227694] dsRNA binds to MDA5 - Gallus gallus
output	[EntityWithAccessionedSequence:R-HSA-918185] TKFC [cytosol] [Complex:R-HSA-913727] viral dsRNA:IFIH1 [cytosol]
relatedSpecies	[Species:9013948] Measles virus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-913725
summation	[Summation:913724] Interferon-induced helicase C domain-containing protein 1 (I...

Referrals

(precedingEvent)	[Reaction:R-HSA-9833393] N interacts with IFIH1 [Reaction:R-HSA-168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
(hasEvent)	[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta