Reactome | DDX58/IFIH1-mediated induction of interferon-alpha/beta

Schema > Pathway > Entries

DDX58/IFIH1-mediated induction of interferon-alpha/beta Show undefined attributes

compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329419
displayName	DDX58/IFIH1-mediated induction of interferon-alpha/beta
eventOf	[Pathway:R-CFA-168249] Innate Immune System - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-CFA-933542] TRAF6 mediated NF-kB activation - Canis familiaris [Pathway:R-CFA-936440] Negative regulators of DDX58/IFIH1 signaling - Canis familiaris [Reaction:R-CFA-9709831] HSP90 binds TBK1 and IRF3 - Canis familiaris [Reaction:R-CFA-9709842] MAVS binds TOMM70 - Canis familiaris
inferredFrom	[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	DDX58/IFIH1-mediated induction of interferon-alpha/beta RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-168928
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-168249] Innate Immune System
(hasEncapsulatedEvent)	[Pathway:R-CFA-1834949] Cytosolic sensors of pathogen-associated DNA
(inferredTo)	[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta

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