Reactome | TRAF6 mediated NF-kB activation

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TRAF6 mediated NF-kB activation Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:933540] Garapati, P V, 2010-08-16
crossReference	[DatabaseIdentifier:12819573] BioModels Database:BIOMD0000000243 [DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	933542
displayName	TRAF6 mediated NF-kB activation
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-933528] Interaction of MEKK1 with TRAF6 - Homo sapiens [Reaction:R-HSA-933530] Activation of IKK by MEKK1 - Homo sapiens [Reaction:R-HSA-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - Homo sapiens [Reaction:R-HSA-168166] NF-kappa-B complex is transported from cytosol to nucleus - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:933430] TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	TRAF6 mediated NF-kB activation
orthologousEvent	[Pathway:R-DME-933542] TRAF6 mediated NF-kB activation - Drosophila melanogaster [Pathway:R-GGA-933542] TRAF6 mediated NF-kB activation - Gallus gallus [Pathway:R-SSC-933542] TRAF6 mediated NF-kB activation - Sus scrofa [Pathway:R-BTA-933542] TRAF6 mediated NF-kB activation - Bos taurus [Pathway:R-CFA-933542] TRAF6 mediated NF-kB activation - Canis familiaris [Pathway:R-RNO-933542] TRAF6 mediated NF-kB activation - Rattus norvegicus [Pathway:R-MMU-933542] TRAF6 mediated NF-kB activation - Mus musculus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-933542
summation	[Summation:933416] The TRAF6/TAK1 signal activates a canonical IKK complex, res...
updateTrackers	[UpdateTracker:9789880] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v37:[updateContainedRLE] [UpdateTracker:9779316] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v65:[updateContainedRLE] [UpdateTracker:9781994] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v60:[updateContainedRLE] [UpdateTracker:9928449] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v91:[modifyText] [UpdateTracker:9778129] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v68:[updateContainedRLE] [UpdateTracker:9774679] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v81:[updateContainedRLE] [UpdateTracker:9788794] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v40:[updateContainedRLE] [UpdateTracker:9774872] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v80:[updateContainedRLE] [UpdateTracker:9775812] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v78:[updateContainedRLE] [UpdateTracker:9788184] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v43:[updateContainedRLE] [UpdateTracker:9787689] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v44:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9789880] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v37:[updateContainedRLE]
[UpdateTracker:9779316] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v65:[updateContainedRLE]
[UpdateTracker:9781994] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v60:[updateContainedRLE]
[UpdateTracker:9928449] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v91:[modifyText]
[UpdateTracker:9778129] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v68:[updateContainedRLE]
[UpdateTracker:9774679] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v81:[updateContainedRLE]
[UpdateTracker:9788794] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v40:[updateContainedRLE]
[UpdateTracker:9774872] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v80:[updateContainedRLE]
[UpdateTracker:9775812] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v78:[updateContainedRLE]
[UpdateTracker:9788184] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v43:[updateContainedRLE]
[UpdateTracker:9787689] Update Tracker - [Pathway:933542] TRAF6 mediated NF-kB activation - v44:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta

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