Reactome | Innate Immune System

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Innate Immune System Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329239
displayName	Innate Immune System
eventOf	[TopLevelPathway:R-CFA-168256] Immune System - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:408] innate immune response
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-CFA-168898] Toll-like Receptor Cascades - Canis familiaris [Pathway:R-CFA-166658] Complement cascade - Canis familiaris [Pathway:R-CFA-168643] Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways - Canis familiaris [Pathway:R-CFA-879415] Advanced glycosylation endproduct receptor signaling - Canis familiaris [Pathway:R-CFA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Canis familiaris [Pathway:R-CFA-1834949] Cytosolic sensors of pathogen-associated DNA - Canis familiaris [Pathway:R-CFA-2029480] Fcgamma receptor (FCGR) dependent phagocytosis - Canis familiaris [Pathway:R-CFA-2172127] DAP12 interactions - Canis familiaris [Pathway:R-CFA-2454202] Fc epsilon receptor (FCERI) signaling - Canis familiaris [Pathway:R-CFA-5621481] C-type lectin receptors (CLRs) - Canis familiaris [Pathway:R-CFA-6803157] Antimicrobial peptides - Canis familiaris [Pathway:R-CFA-6798695] Neutrophil degranulation - Canis familiaris [Pathway:R-CFA-1222556] ROS and RNS production in phagocytes - Canis familiaris [Pathway:R-CFA-9645460] Alpha-protein kinase 1 signaling pathway - Canis familiaris [Pathway:R-CFA-9970672] FXIIa activates plasma kallikrein-kinin system - Canis familiaris
inferredFrom	[Pathway:R-HSA-168249] Innate Immune System - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	10
name	Innate Immune System
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-168249
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-CFA-168256] Immune System
(hasEncapsulatedEvent)	[Pathway:R-CFA-5633008] TP53 Regulates Transcription of Cell Death Genes
(inferredTo)	[Pathway:R-HSA-168249] Innate Immune System

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