Reactome | Neutrophil degranulation

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Neutrophil degranulation Show undefined attributes

authored	[InstanceEdit:6798688] Jupe, Steve, 2015-09-21
created	[InstanceEdit:6798688] Jupe, Steve, 2015-09-21
dbId	6798695
displayName	Neutrophil degranulation
doi	10.3180/R-HSA-6798695.1
edited	[InstanceEdit:8876341] Jupe, Steve, 2016-06-13
eventOf	[Pathway:R-HSA-168249] Innate Immune System - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:161034] neutrophil degranulation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-6798751] Exocytosis of azurophil granule lumen proteins - Homo sapiens [Reaction:R-HSA-6798739] Exocytosis of azurophil granule membrane proteins - Homo sapiens [Reaction:R-HSA-6798749] Exocytosis of specific granule lumen proteins - Homo sapiens [Reaction:R-HSA-6799350] Exocytosis of specific granule membrane proteins - Homo sapiens [Reaction:R-HSA-6798745] Exocytosis of tertiary granule lumen proteins - Homo sapiens [Reaction:R-HSA-6798747] Exocytosis of tertiary granule membrane proteins - Homo sapiens [Reaction:R-HSA-6800434] Exocytosis of ficolin-rich granule lumen proteins - Homo sapiens [Reaction:R-HSA-6800426] Exocytosis of ficolin-rich granule membrane proteins - Homo sapiens [Reaction:R-HSA-6798748] Exocytosis of secretory granule lumen proteins - Homo sapiens [Reaction:R-HSA-6798743] Exocytosis of secretory granule membrane proteins - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6806034] Neutrophil function in inflammation and inflammatory diseases [LiteratureReference:6806079] Neutrophil granules: a library of innate immunity proteins [LiteratureReference:6806041] Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors [LiteratureReference:6798689] Stimulus-dependent secretion of plasma proteins from human neutrophils [LiteratureReference:6798694] Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Neutrophil degranulation
orthologousEvent	[Pathway:R-MMU-6798695] Neutrophil degranulation - Mus musculus [Pathway:R-PFA-6798695] Neutrophil degranulation - Plasmodium falciparum [Pathway:R-SCE-6798695] Neutrophil degranulation - Saccharomyces cerevisiae [Pathway:R-SPO-6798695] Neutrophil degranulation - Schizosaccharomyces pombe [Pathway:R-DDI-6798695] Neutrophil degranulation - Dictyostelium discoideum [Pathway:R-CEL-6798695] Neutrophil degranulation - Caenorhabditis elegans [Pathway:R-DME-6798695] Neutrophil degranulation - Drosophila melanogaster [Pathway:R-GGA-6798695] Neutrophil degranulation - Gallus gallus [Pathway:R-XTR-6798695] Neutrophil degranulation - Xenopus tropicalis [Pathway:R-DRE-6798695] Neutrophil degranulation - Danio rerio [Pathway:R-SSC-6798695] Neutrophil degranulation - Sus scrofa [Pathway:R-BTA-6798695] Neutrophil degranulation - Bos taurus [Pathway:R-CFA-6798695] Neutrophil degranulation - Canis familiaris [Pathway:R-RNO-6798695] Neutrophil degranulation - Rattus norvegicus
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8876294] Heegaard, Niels, 2016-06-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6798695
summation	[Summation:6798697] Neutrophils are the most abundant leukocytes (white blood ce...

Referrals

(hasEncapsulatedEvent)	[Pathway:R-HSA-9920588] Dengue virus activates/modulates innate and adaptive immune responses
(hasEvent)	[Pathway:R-HSA-168249] Innate Immune System

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