Reactome | TP53 Regulates Transcription of Cell Death Genes

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authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created	[InstanceEdit:5633006] Orlic-Milacic, Marija, 2014-10-29
dbId	5633008
displayName	TP53 Regulates Transcription of Cell Death Genes
doi	10.3180/r-hsa-5633008.1
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:139812] regulation of apoptotic process
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-6803211] TP53 Regulates Transcription of Death Receptors and Ligands - Homo sapiens [Pathway:R-HSA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Homo sapiens [Pathway:R-HSA-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases - Homo sapiens [Pathway:R-HSA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5633431] KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene [LiteratureReference:5633440] Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site [LiteratureReference:5633427] Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene [LiteratureReference:5633411] p53 upregulates death receptor 4 expression through an intronic p53 binding site [LiteratureReference:5633426] Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site [LiteratureReference:5633429] Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity [LiteratureReference:6799811] Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family [LiteratureReference:6799802] ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo [LiteratureReference:3700985] Tumor suppressor p53 is a direct transcriptional activator of the human bax gene [LiteratureReference:140387] Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis [LiteratureReference:6799772] ASPP proteins specifically stimulate the apoptotic function of p53 [LiteratureReference:140450] PUMA, a novel proapoptotic gene, is induced by p53 [LiteratureReference:6791288] BID regulation by p53 contributes to chemosensitivity [LiteratureReference:6801169] The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase [LiteratureReference:6799791] ASPP1 and ASPP2: common activators of p53 family members [LiteratureReference:140442] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53 [LiteratureReference:6800029] Induction of the growth inhibitor IGF-binding protein 3 by p53 [LiteratureReference:6800045] Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer [LiteratureReference:6798000] Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth [LiteratureReference:6791300] AMID is a p53-inducible gene downregulated in tumors [LiteratureReference:6801207] p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway [LiteratureReference:6799790] Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax [LiteratureReference:6800007] iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes [LiteratureReference:6800275] Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis [LiteratureReference:6791355] APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis [LiteratureReference:6798096] Direct transcriptional activation of human caspase-1 by tumor suppressor p53 [LiteratureReference:6798128] Apoptotic threshold is lowered by p53 transactivation of caspase-6 [LiteratureReference:6798143] Caspase 10 levels are increased following DNA damage in a p53-dependent manner [LiteratureReference:6801360] Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis [LiteratureReference:451670] Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death [LiteratureReference:6800838] PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family [LiteratureReference:6791335] Bcl-G, a novel pro-apoptotic member of the Bcl-2 family [LiteratureReference:6799447] A polymorphic microsatellite that mediates induction of PIG3 by p53 [LiteratureReference:6800842] Perp is a p63-regulated gene essential for epithelial integrity [LiteratureReference:5633302] NDRG1 is necessary for p53-dependent apoptosis [LiteratureReference:6800259] The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells [LiteratureReference:5628898] Identification of novel p53 target genes in ionizing radiation response [LiteratureReference:6800261] BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma [LiteratureReference:5633304] p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion [LiteratureReference:6800238] BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma [LiteratureReference:6800848] P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma [LiteratureReference:6791332] Bcl-2 family member Bcl-G is not a proapoptotic protein [LiteratureReference:6798366] DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage [LiteratureReference:3215254] p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis [LiteratureReference:3215228] TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity [LiteratureReference:6798080] Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin [LiteratureReference:6801427] Perp is a mediator of p53-dependent apoptosis in diverse cell types [LiteratureReference:6798097] Caspase-1 is a novel target of p63 in tumor suppression [LiteratureReference:6801440] Transcriptional control of human p53-regulated genes [LiteratureReference:6801441] A complex barcode underlies the heterogeneous response of p53 to stress [LiteratureReference:6801433] Unravelling mechanisms of p53-mediated tumour suppression [LiteratureReference:6801439] p53 in survival, death and metabolic health: a lifeguard with a licence to kill
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	TP53 Regulates Transcription of Cell Death Genes
orthologousEvent	[Pathway:R-CEL-5633008] TP53 Regulates Transcription of Cell Death Genes - Caenorhabditis elegans [Pathway:R-DRE-5633008] TP53 Regulates Transcription of Cell Death Genes - Danio rerio [Pathway:R-BTA-5633008] TP53 Regulates Transcription of Cell Death Genes - Bos taurus [Pathway:R-SSC-5633008] TP53 Regulates Transcription of Cell Death Genes - Sus scrofa [Pathway:R-XTR-5633008] TP53 Regulates Transcription of Cell Death Genes - Xenopus tropicalis [Pathway:R-DME-5633008] TP53 Regulates Transcription of Cell Death Genes - Drosophila melanogaster [Pathway:R-DDI-5633008] TP53 Regulates Transcription of Cell Death Genes - Dictyostelium discoideum [Pathway:R-SPO-5633008] TP53 Regulates Transcription of Cell Death Genes - Schizosaccharomyces pombe [Pathway:R-GGA-5633008] TP53 Regulates Transcription of Cell Death Genes - Gallus gallus [Pathway:R-SCE-5633008] TP53 Regulates Transcription of Cell Death Genes - Saccharomyces cerevisiae [Pathway:R-PFA-5633008] TP53 Regulates Transcription of Cell Death Genes - Plasmodium falciparum [Pathway:R-MMU-5633008] TP53 Regulates Transcription of Cell Death Genes - Mus musculus [Pathway:R-RNO-5633008] TP53 Regulates Transcription of Cell Death Genes - Rattus norvegicus [Pathway:R-CFA-5633008] TP53 Regulates Transcription of Cell Death Genes - Canis familiaris
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5633008
summation	[Summation:6801419] The tumor suppressor TP53 (p53) exerts its tumor suppressive...

Referrals

(hasEvent)	[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53
(hasEncapsulatedEvent)	[Pathway:R-HSA-6791312] TP53 Regulates Transcription of Cell Cycle Genes [Pathway:R-HSA-6804759] Regulation of TP53 Activity through Association with Co-factors

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