Reactome | Innate Immune System

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Innate Immune System Show undefined attributes

created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11128516
displayName	Innate Immune System
eventOf	[TopLevelPathway:R-PFA-168256] Immune System - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:408] innate immune response
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-PFA-168898] Toll-like Receptor Cascades - Plasmodium falciparum [Pathway:R-PFA-1834949] Cytosolic sensors of pathogen-associated DNA - Plasmodium falciparum [Pathway:R-PFA-2454202] Fc epsilon receptor (FCERI) signaling - Plasmodium falciparum [Pathway:R-PFA-5621481] C-type lectin receptors (CLRs) - Plasmodium falciparum [Pathway:R-PFA-6803157] Antimicrobial peptides - Plasmodium falciparum [Pathway:R-PFA-6798695] Neutrophil degranulation - Plasmodium falciparum [Pathway:R-PFA-1222556] ROS and RNS production in phagocytes - Plasmodium falciparum
inferredFrom	[Pathway:R-HSA-168249] Innate Immune System - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	8
name	Innate Immune System
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-168249
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-PFA-168256] Immune System
(hasEncapsulatedEvent)	[Pathway:R-PFA-5633008] TP53 Regulates Transcription of Cell Death Genes
(inferredTo)	[Pathway:R-HSA-168249] Innate Immune System

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