Reactome | Innate Immune System

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Innate Immune System Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099149
displayName	Innate Immune System
eventOf	[TopLevelPathway:R-MMU-168256] Immune System - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:408] innate immune response
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-MMU-168898] Toll-like Receptor Cascades - Mus musculus [Pathway:R-MMU-166658] Complement cascade - Mus musculus [Pathway:R-MMU-168643] Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways - Mus musculus [Pathway:R-MMU-879415] Advanced glycosylation endproduct receptor signaling - Mus musculus [Pathway:R-MMU-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Mus musculus [Pathway:R-MMU-1834949] Cytosolic sensors of pathogen-associated DNA - Mus musculus [Pathway:R-MMU-2029480] Fcgamma receptor (FCGR) dependent phagocytosis - Mus musculus [Pathway:R-MMU-2172127] DAP12 interactions - Mus musculus [Pathway:R-MMU-2454202] Fc epsilon receptor (FCERI) signaling - Mus musculus [Pathway:R-MMU-5621481] C-type lectin receptors (CLRs) - Mus musculus [Pathway:R-MMU-6803157] Antimicrobial peptides - Mus musculus [Pathway:R-MMU-6798695] Neutrophil degranulation - Mus musculus [Pathway:R-MMU-1222556] ROS and RNS production in phagocytes - Mus musculus [Pathway:R-MMU-9645460] Alpha-protein kinase 1 signaling pathway - Mus musculus [Pathway:R-MMU-9686114] Non-canonical inflammasome activation - Mus musculus [Pathway:R-MMU-9970672] FXIIa activates plasma kallikrein-kinin system - Mus musculus
inferredFrom	[Pathway:R-HSA-168249] Innate Immune System - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	10
name	Innate Immune System
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-168249
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-MMU-168256] Immune System
(hasEncapsulatedEvent)	[Pathway:R-MMU-5633008] TP53 Regulates Transcription of Cell Death Genes
(inferredTo)	[Pathway:R-HSA-168249] Innate Immune System

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