Reactome | Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants

Schema > Reaction > Entries

Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1225927] protein tyrosine kinase activity of Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1225955] Orlic-Milacic, Marija, 2011-03-03
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1225952
disease	[Disease:1500689] cancer
displayName	Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5637731] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]
eventOf	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
followingEvent	[Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-1225858] Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants
normalReaction	[Reaction:R-HSA-177933] SHC1 phosphorylation by phosphorylated EGFR
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1225854] Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1225947] Binding of SHC1 to p-6Y-EGFR mutants - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1225952
summation	[Summation:1225954] Constitutive phosphorylation of SHC1 was directly demonstrat...

Referrals

(precedingEvent)	[Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex
(hasEvent)	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

Cite Us!