Reactome | Binding of SHC1 to p-6Y-EGFR mutants

Schema > Reaction > Entries

Binding of SHC1 to p-6Y-EGFR mutants Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1225955] Orlic-Milacic, Marija, 2011-03-03
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1225947
disease	[Disease:1500689] cancer
displayName	Binding of SHC1 to p-6Y-EGFR mutants
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5637728] gain_of_function of Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane]
eventOf	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
followingEvent	[Reaction:R-HSA-5637796] Phosphorylation of SHC1 by p-5Y-EGFRvIII - Homo sapiens [Reaction:R-HSA-1225952] Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants - Homo sapiens
input	[DefinedSet:R-HSA-1181062] Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] [EntityWithAccessionedSequence:R-HSA-74680] SHC1 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1225829] Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways [LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants [LiteratureReference:2008120] EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes [LiteratureReference:1248637] Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII [LiteratureReference:2008136] Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition [LiteratureReference:1248643] Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Binding of SHC1 to p-6Y-EGFR mutants
normalReaction	[Reaction:R-HSA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex
output	[Complex:R-HSA-1225858] Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers - Homo sapiens [Reaction:R-HSA-1248655] Trans-autophosphorylation of EGFRvIII mutant dimers - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1225947
summation	[Summation:1247600] SHC1 (Src homology 2 domain-containing transforming protein)...
updateTrackers	[UpdateTracker:9835694] Update Tracker - [Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants - v85:[modifyText] [UpdateTracker:9785574] Update Tracker - [Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants - v51:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9835694] Update Tracker - [Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants - v85:[modifyText] [UpdateTracker:9785574] Update Tracker - [Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants - v51:[add_removeInput]
(precedingEvent)	[Reaction:R-HSA-5637796] Phosphorylation of SHC1 by p-5Y-EGFRvIII [Reaction:R-HSA-1225952] Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants
(hasEvent)	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

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