Reactome | Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors

Schema > Reaction > Entries

Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1220609] Orlic-Milacic, Marija, 2011-02-22
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1220611
disease	[Disease:1500689] cancer
displayName	Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990858] Jassal, B, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
eventOf	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
input	2 × [DefinedSet:R-ALL-1216522] Covalent EGFR tyrosine kinase inhibitors [cytosol] [DefinedSet:R-HSA-1220585] Resistant ligand-responsive EGFR mutants [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1225967] Novel mutant-selective EGFR kinase inhibitors against EGFR T790M [LiteratureReference:2008190] Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors
output	[Complex:R-HSA-1220579] Resistant ligand-responsive EGFR mutants:Covalent EGFR TKIs [plasma membrane]
precedingEvent	[Reaction:R-HSA-1220610] Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1220611
summation	[Summation:1225971] Covalent (irreversible) tyrosine kinase inhibitors (TKIs), p...

Referrals

(hasEvent)

[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

Cite Us!