Reactome | Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants

Schema > Reaction > Entries

Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1247843] protein tyrosine kinase activity of Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1247840] Orlic-Milacic, Marija, 2011-04-07
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1247844
disease	[Disease:1500689] cancer
displayName	Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5637726] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane]
eventOf	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
followingEvent	[Reaction:R-HSA-1247842] Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-1247845] Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:212708] Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro [LiteratureReference:212704] Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants
normalReaction	[Reaction:R-HSA-212710] EGFR activates PLC-gamma1 by phosphorylation
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1247846] Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1247841] PLCG1 binds to ligand-responsive p-6Y-EGFR mutants - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1247844
summation	[Summation:1247837] Once recruited, PLC-gamma 1 is assumed to be phosphorylated ...

Referrals

(hasEvent)	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
(precedingEvent)	[Reaction:R-HSA-1247842] Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants

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