Reactome | Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:9037681] ubiquitin protein ligase activity of Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1225955] Orlic-Milacic, Marija, 2011-03-03
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1225956
disease	[Disease:1500689] cancer
displayName	Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990852] Gillespie, ME, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5637714] loss_of_function of Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane]
eventOf	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
input	[Complex:R-HSA-1225857] Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane] 2 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1225925] Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized [LiteratureReference:1225923] Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL
normalReaction	[Reaction:R-HSA-182993] Ubiquitination of stimulated EGFR (CBL)
precedingEvent	[Reaction:R-HSA-1225960] Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-1225948] Negative regulation by 'Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane]'
regulationReference	[RegulationReference:9642194] Negative regulation by 'Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane]' Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1225956
summation	[Summation:1225959] Phosphorylated CBL does not ubiquitinate EGFR kinase domain ...
updateTrackers	[UpdateTracker:9785591] Update Tracker - [FailedReaction:1225956] Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL - v51:[removeOutput] [UpdateTracker:9779860] Update Tracker - [FailedReaction:1225956] Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL - v64:[addCatalystActivity] [UpdateTracker:9776001] Update Tracker - [FailedReaction:1225956] Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL - v78:[modifyText] [UpdateTracker:9785254] Update Tracker - [FailedReaction:1225956] Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL - v52:[removeCatalystActivity]

Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL Show undefined attributes

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