Reactome | Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants

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Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
category	dissociation
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1247840] Orlic-Milacic, Marija, 2011-04-07
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1247842
disease	[Disease:1500689] cancer
displayName	Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5637719] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane]
eventOf	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
input	[Complex:R-HSA-1247846] Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1225829] Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants
normalReaction	[Reaction:R-HSA-212713] Active PLC-gamma1 dissociates from EGFR
output	[DefinedSet:R-HSA-1181062] Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] [EntityWithAccessionedSequence:R-HSA-167679] p-4Y-PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1247844] Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1247842
summation	[Summation:1247839] Once phosphorylated, PLC-gamma 1 is expected to dissociate f...
updateTrackers	[UpdateTracker:9785670] Update Tracker - [Reaction:1247842] Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants - v51:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9785670] Update Tracker - [Reaction:1247842] Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants - v51:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

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