Reactome | EGF-induced dimerization of ligand-responsive EGFR mutants

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EGF-induced dimerization of ligand-responsive EGFR mutants Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1220609] Orlic-Milacic, Marija, 2011-02-22
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1220613
disease	[Disease:1500689] cancer
displayName	EGF-induced dimerization of ligand-responsive EGFR mutants
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5637729] gain_of_function of EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane]
eventOf	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
followingEvent	[Reaction:R-HSA-1220610] Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants - Homo sapiens [Reaction:R-HSA-1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers - Homo sapiens
input	2 × [DefinedSet:R-HSA-1220578] EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1181011] An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor [LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants [LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity [LiteratureReference:1181025] The juxtamembrane region of the EGF receptor functions as an activation domain
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGF-induced dimerization of ligand-responsive EGFR mutants
normalReaction	[Reaction:R-HSA-177922] EGFR dimerization
output	[Complex:R-HSA-1500847] EGF:Ligand-responsive EGFR mutants dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-1220612] Binding of EGF to ligand-responsive EGFR mutants - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1220613
summation	[Summation:1247597] Although ligand-responsive EGFR mutants dimerize spontaneous...

Referrals

(hasEvent)	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
(precedingEvent)	[Reaction:R-HSA-1220610] Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants [Reaction:R-HSA-1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers

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