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Schema
>
Reaction
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Entries
Phosphorylation and activation of PLCG due to FCGR3A effect
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authored
[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
catalystActivity
[CatalystActivity:2029255] protein tyrosine kinase activity of clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9643489] protein tyrosine kinase activity of clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created
[InstanceEdit:9664264] Murillo, Julieth, 2019-10-22
dbId
9664278
disease
[Disease:9674660] cutaneous leishmaniasis
displayName
Phosphorylation and activation of PLCG due to FCGR3A effect
edited
[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
eventOf
[Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis - Homo sapiens
followingEvent
[Reaction:R-HSA-9664271] Release of PLCG from FCGR3A - Homo sapiens
input
3 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-9664266] IgG:Leishmania surface:p-FCGR3As:p-6Y-SYK:PLCG [plasma membrane]
[SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:2028806] Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
[LiteratureReference:2028992] Tyrosine phosphorylation of phospholipase C-gamma 2 is involved in the activation of phosphoinositide hydrolysis by Fc receptors in human neutrophils
[LiteratureReference:1168981] Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Phosphorylation and activation of PLCG due to FCGR3A effect
output
3 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-9664277] IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:p-3Y-PLCG [plasma membrane]
precedingEvent
[Reaction:R-HSA-9664270] Recruitment of PLCgamma to membrane due to FCGR3A effect - Homo sapiens
relatedSpecies
[Species:9658193] Leishmania major
releaseDate
2020-03-17
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9675734] Gregory, David J, 2020-02-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9664278
summation
[Summation:2028840] PLCG is tyrosine phosphorylated by either SYK or Src kinases...
Referrals
(hasEvent)
[Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis
(precedingEvent)
[Reaction:R-HSA-9664271] Release of PLCG from FCGR3A
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