Reactome | FCGR3A-mediated IL10 synthesis

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FCGR3A-mediated IL10 synthesis Show undefined attributes

authored	[InstanceEdit:9673371] Jassal, Bijay, 2020-01-07 [InstanceEdit:9673290] Murillo, Julieth, 2020-01-07
created	[InstanceEdit:9664349] Murillo, Julieth, 2019-10-22
crossReference	[DatabaseIdentifier:12020756] Mondo:0005446
dbId	9664323
disease	[Disease:9674660] cutaneous leishmaniasis
displayName	FCGR3A-mediated IL10 synthesis
edited	[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
eventOf	[Pathway:R-HSA-9662851] Anti-inflammatory response favouring Leishmania parasite infection - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:258635] negative regulation of inflammatory response to antigenic stimulus
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9664397] IgG binds LPG1G2 in the amastigote form of Leishmania - Homo sapiens [Reaction:R-HSA-9664285] IgG binds the surface of the amastigote form of Leishmania - Homo sapiens [Reaction:R-HSA-9664268] Opsonized leishmania amastigote binds FCGR3 - Homo sapiens [Reaction:R-HSA-9664275] Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers - Homo sapiens [Reaction:R-HSA-9664273] SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers - Homo sapiens [Reaction:R-HSA-9664261] Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK - Homo sapiens [Reaction:R-HSA-9664270] Recruitment of PLCgamma to membrane due to FCGR3A effect - Homo sapiens [Reaction:R-HSA-9664278] Phosphorylation and activation of PLCG due to FCGR3A effect - Homo sapiens [Reaction:R-HSA-9664271] Release of PLCG from FCGR3A - Homo sapiens [Reaction:R-HSA-202407] PLC-gamma1 hydrolyses PIP2 - Homo sapiens [Reaction:R-HSA-169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel - Homo sapiens [Reaction:R-HSA-169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol - Homo sapiens [Reaction:R-HSA-74448] Calcium binds calmodulin - Homo sapiens [Reaction:R-HSA-111930] Adenylate cyclase produces cAMP - Homo sapiens [Reaction:R-HSA-8951727] cAMP binds PKA tetramer - Homo sapiens [Reaction:R-HSA-111925] cAMP induces dissociation of inactive PKA tetramers - Homo sapiens [Reaction:R-HSA-111924] PKA catalytic subunit translocates to the nucleus - Homo sapiens [Reaction:R-HSA-111919] PKA phosphorylates CREB1 - Homo sapiens [Reaction:R-HSA-9664332] CREB1 binds IL-10 promoter - Homo sapiens [BlackBoxEvent:R-HSA-9664346] IL10 gene produces IL10 protein - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:9664347] Interleukin-10 therapy--review of a new approach [LiteratureReference:9664321] Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages [LiteratureReference:9664259] IgG1 is pathogenic in Leishmania mexicana infection [LiteratureReference:9664318] IL-10 Production in Macrophages Is Regulated by a TLR-Driven CREB-Mediated Mechanism That Is Linked to Genes Involved in Cell Metabolism
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	FCGR3A-mediated IL10 synthesis
relatedSpecies	[Species:9658193] Leishmania major
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9664323
summation	[Summation:9664336] Interleukin 10 (IL-10) is an important immunoregulatory cyto...
updateTrackers	[UpdateTracker:9864122] Update Tracker - [Pathway:9664323] FCGR3A-mediated IL10 synthesis - v88:[updateContainedRLE] [UpdateTracker:9846703] Update Tracker - [Pathway:9664323] FCGR3A-mediated IL10 synthesis - v84:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9864122] Update Tracker - [Pathway:9664323] FCGR3A-mediated IL10 synthesis - v88:[updateContainedRLE] [UpdateTracker:9846703] Update Tracker - [Pathway:9664323] FCGR3A-mediated IL10 synthesis - v84:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9662851] Anti-inflammatory response favouring Leishmania parasite infection

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