Reactome | Recruitment of PLCgamma to membrane due to FCGR3A effect

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Recruitment of PLCgamma to membrane due to FCGR3A effect Show undefined attributes

authored	[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9664264] Murillo, Julieth, 2019-10-22
crossReference	[DatabaseIdentifier:12020756] Mondo:0005446
dbId	9664270
disease	[Disease:9674660] cutaneous leishmaniasis
displayName	Recruitment of PLCgamma to membrane due to FCGR3A effect
edited	[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
eventOf	[Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-9664278] Phosphorylation and activation of PLCG due to FCGR3A effect - Homo sapiens
input	[Complex:R-HSA-9664265] IgG:Lma antigens:FCGR3A:p-CD3 dimers:p-6Y-SYK [plasma membrane] [DefinedSet:R-HSA-1169089] PLC gamma1,2 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2028806] Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk [LiteratureReference:2028992] Tyrosine phosphorylation of phospholipase C-gamma 2 is involved in the activation of phosphoinositide hydrolysis by Fc receptors in human neutrophils
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of PLCgamma to membrane due to FCGR3A effect
output	[Complex:R-HSA-9664266] IgG:Leishmania surface:p-FCGR3As:p-6Y-SYK:PLCG [plasma membrane]
precedingEvent	[Reaction:R-HSA-9664261] Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK - Homo sapiens
relatedSpecies	[Species:9658193] Leishmania major
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9664270
summation	[Summation:2028868] PLCgamma (PLCG) is recruited to FCGR and the phosphorylated ...

Referrals

(hasEvent)	[Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis
(precedingEvent)	[Reaction:R-HSA-9664278] Phosphorylation and activation of PLCG due to FCGR3A effect

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