Reactome | PTPN2-1 [nucleoplasm]

PTPN2-1 [nucleoplasm]

Stable Identifier

R-HSA-997295

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TC-PTPa, TC45, Tyrosine-protein phosphatase non-receptor type 2 isoform 1, PTN2_HUMAN, PTPN2 isoform 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P17706-2 PTPN2

Gene Names

PTPN2, PTPT

Other Identifiers

11738863_a_at

11739325_a_at

11739326_a_at

1264_at

1265_g_at

1557193_PM_at

1557193_at

16854064

204935_PM_at

204935_at

213136_PM_at

213136_at

213137_PM_s_at

213137_s_at

2445972

2445973

2445974

3409459

37893_at

3799616

3799627

3799628

3799629

3799630

3799631

3799632

3799633

3799634

3799637

3799639

3799641

3799642

3799644

3799650

3799651

3799652

3799657

3799662

3799663

3799666

3799667

3799670

3799671

3799673

5771

8022393

A_23_P309701

GE57884

GO:0000122

GO:0002376

GO:0003824

GO:0004721

GO:0004725

GO:0004726

GO:0005178

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005783

GO:0005793

GO:0005829

GO:0005886

GO:0005975

GO:0006351

GO:0006355

GO:0006470

GO:0006954

GO:0007155

GO:0008285

GO:0008286

GO:0010804

GO:0010888

GO:0012501

GO:0016020

GO:0016311

GO:0016787

GO:0016791

GO:0019901

GO:0019905

GO:0023052

GO:0030154

GO:0030183

GO:0030217

GO:0030218

GO:0030971

GO:0031410

GO:0031904

GO:0035335

GO:0036211

GO:0038020

GO:0042059

GO:0042532

GO:0042593

GO:0043226

GO:0045650

GO:0045722

GO:0046426

GO:0046627

GO:0048856

GO:0050728

GO:0050860

GO:0050922

GO:0060334

GO:0060336

GO:0060339

GO:0070104

GO:0070373

GO:0097677

GO:0098542

GO:0140096

GO:1902202

GO:1902206

GO:1902215

GO:1902227

GO:1902233

GO:1902237

GO:1903899

GO:2000587

HMNXSV003026540

HMNXSV003056697

Hs.82829.1.A1_3p_a_at

Hs2.255158.1.A1_3p_at

ILMN_2296036

ILMN_2296037

ILMN_2400030

M25393_at

PH_hs_0013444

PH_hs_0026071

TC18000377.hg

g4506290_3p_at

Inferred To

PTPN2 [nucleoplasm] (Canis familiaris)

PTPN2-1 [nucleoplasm] (Bos taurus)

PTPN2-1 [nucleoplasm] (Danio rerio)

PTPN2-1 [nucleoplasm] (Drosophila melanogaster)

PTPN2-1 [nucleoplasm] (Gallus gallus)

PTPN2-1 [nucleoplasm] (Mus musculus)

PTPN2-1 [nucleoplasm] (Rattus norvegicus)

PTPN2-1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_536347.1, NP_536348.1, NP_002819.2, NP_001193942.1

Guide to Pharmacology - Targets

3255

OpenTargets

ENSG00000175354

ZINC - Substances

PTN2_HUMAN

ZINC target

P17706

ZINC - Biogenic

PTN2_HUMAN

PRO

P17706

PDB

7F5O, 1L8K, 7UAD, 7F5N, 6ZZ4

ZINC - Metabolites

PTN2_HUMAN

GeneCards

P17706

HPA

ENSG00000175354-PTPN2

Ensembl

ENSP00000466936, ENST00000353319, ENST00000591115, ENST00000309660, ENSP00000320298, ENSP00000320546, ENST00000327283, ENSG00000175354, ENSP00000311857

Pharos - Targets

P17706

Orphanet

21211

ZINC - Predictions - Purchasable

PTN2_HUMAN

HMDB Protein

HMDBP08934

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10912 GHR	7	p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226) GHR(257-638) [plasma membrane] (R-HSA-1168803) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(19-638) [endosome lumen] (R-HSA-1169263) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR activated [plasma membrane] (R-HSA-1168385)	0.645	8
UniProt:P20908 COL5A1	20	3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023553) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023664) GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023513) GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023628) 3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023564) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023647) COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022460) 3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022510) 3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022483) 3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022948) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022970) 5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022989) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268653) COL5A1(38-1838) [extracellular region] (R-HSA-2268703) 3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268718) 3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268664) 3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region] (R-HSA-2268667) GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268629) 5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268644) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268663)	0.589	2
UniProt:Q2GHU2 Q2GHU2			0.557	4
UniProt:Q9P296 C5AR2	1	C5AR2 [plasma membrane] (R-HSA-964798)	0.527	2
UniProt:O43505 B4GAT1	1	B4GAT1 [Golgi membrane] (R-HSA-916821)	0.527	3
UniProt:Q6ZMH5 SLC39A5	1	SLC39A5 [plasma membrane] (R-HSA-442360)	0.527	2
UniProt:P07306 ASGR1	1	PALM-C36-ASGR1 [plasma membrane] (R-HSA-8855714)	0.527	2
UniProt:P32971 TNFSF8	1	TNFSF8 [plasma membrane] (R-HSA-5667148)	0.527	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [azurophil granule membrane] (R-HSA-6799517) C3AR1 [specific granule membrane] (R-HSA-6799516)	0.527	2
UniProt:P56199 ITGA1	1	ITGA1 [plasma membrane] (R-HSA-215939)	0.463	2

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