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C3AR1 [plasma membrane]
Stable Identifier
R-HSA-444727
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
C3a anaphylatoxin chemotactic receptor, C3AR_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
ATP translocates from cytosol to extracellular space (stimuated by C3AR1:C3a) (Homo sapiens)
C3AR1:C3a [plasma membrane] (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
C3a receptor binds anaphylatoxin C3a (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
C3AR1:C3a [plasma membrane] (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
C3a receptor binds anaphylatoxin C3a (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
C3AR1:C3a [plasma membrane] (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule membrane proteins (Homo sapiens)
Azurophil granule membrane proteins [plasma membrane] (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
C3AR1:C3a [plasma membrane] (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
C3AR1:C3a [plasma membrane] (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
C3AR1:C3a [plasma membrane] (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
C3AR1:C3a [plasma membrane] (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
C3AR1:C3a [plasma membrane] (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
C3AR1:C3a [plasma membrane] (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
C3a receptor binds anaphylatoxin C3a (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
C3AR1:C3a [plasma membrane] (Homo sapiens)
C3AR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16581 C3AR1
Gene Names
C3AR1, AZ3B, C3R1, HNFAG09
Chain
chain:1-482
Reference Genes
BioGPS Gene:719 C3AR1
COSMIC (genes):C3AR1 C3AR1
CTD Gene:719 C3AR1
dbSNP Gene:719 C3AR1
ENSEMBL:ENSG00000171860 C3AR1
HGNC:1319 C3AR1
KEGG:hsa:719 C3AR1
Monarch:719 C3AR1
NCBI Gene:719 C3AR1
OMIM:605246 C3AR1
UCSC:Q16581 C3AR1
Reference Transcript
RefSeq:NM_001326475.1 C3AR1
RefSeq:NM_001326477.1 C3AR1
RefSeq:NM_004054.3 C3AR1
Other Identifiers
11721099_at
16760889
209906_PM_at
209906_at
32068_at
3442938
3442940
3442942
3442943
3442944
3442945
3442946
3442947
3442948
3442949
3442950
3442951
3442952
3442954
719
7960874
A_23_P2431
GE565218
GE59287
GO:0002376
GO:0002430
GO:0002682
GO:0003013
GO:0004875
GO:0004876
GO:0004878
GO:0004930
GO:0005886
GO:0006935
GO:0006954
GO:0007186
GO:0007200
GO:0007204
GO:0008015
GO:0010575
GO:0010759
GO:0016020
GO:0019722
GO:0035577
GO:0035579
GO:0038178
GO:0045766
GO:0060089
GO:0090023
HMNXSV003040667
ILMN_1787529
PH_hs_0009397
TC12001171.hg
U28488_s_at
g1511643_3p_at
Participates
as a member of
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
Azurophil granule membrane proteins [plasma membrane] (Homo sapiens)
as an input of
C3a receptor binds anaphylatoxin C3a (Homo sapiens)
as a component of
C3AR1:C3a [plasma membrane] (Homo sapiens)
Other forms of this molecule
C3AR1 [azurophil granule membrane]
C3AR1 [specific granule membrane]
Inferred To
c3ar1 [plasma membrane]
(Xenopus tropicalis)
C3ar1 [plasma membrane]
(Mus musculus)
C3ar1 [plasma membrane]
(Rattus norvegicus)
C3AR1 [plasma membrane]
(Bos taurus)
C3AR1 [plasma membrane]
(Canis familiaris)
C3AR1 [plasma membrane]
(Gallus gallus)
Cross References
RefSeq
NP_001313404.1
,
NP_004045.1
,
NP_001313406.1
Guide to Pharmacology - Targets
31
OpenTargets
ENSG00000171860
ENSEMBL
ENST00000307637
,
ENSP00000302079
HPA
ENSG00000171860-C3AR1
ZINC - Substances
C3AR_HUMAN
ZINC target
Q16581
PRO
Q16581
Pharos - Targets
Q16581
ZINC - Predictions - Purchasable
C3AR_HUMAN
PDB
8HK2
,
8I97
,
8I95
,
8J6D
,
8HK3
,
8I9S
,
8IA8
,
8JA3
,
8I9L
,
8I9A
Interactors (52)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NY26 SLC39A1
1
SLC39A1 [plasma membrane]
(R-HSA-442329)
0.527
2
UniProt:Q6P1Q0 LTMD1
0.527
2
UniProt:Q8N2A8 PLD6
2
PLD6 [endoplasmic reticulum membrane]
(R-HSA-1498811)
PLD6 [mitochondrial outer membrane]
(R-HSA-5601898)
0.527
2
UniProt:Q9NX00 TM160
0.527
2
UniProt:Q96G23 CERS2
1
CERS2 [endoplasmic reticulum membrane]
(R-HSA-428171)
0.527
2
UniProt:P18031 PTPN1
2
PTPN1 [endosome membrane]
(R-HSA-9815895)
PTPN1 [cytosol]
(R-HSA-210625)
0.527
2
UniProt:P30519 HMOX2
3
HMOX2 [endoplasmic reticulum membrane]
(R-HSA-189391)
HMOX2 [specific granule membrane]
(R-HSA-6799628)
HMOX2 [plasma membrane]
(R-HSA-6799676)
0.527
2
UniProt:Q9GZM5 YIPF3
0.527
2
UniProt:Q6P1A2 LPCAT3
1
LPCAT3 [endoplasmic reticulum membrane]
(R-HSA-428994)
0.527
2
UniProt:P17706 PTPN2
3
p-PTPN2 [cytosol]
(R-HSA-9836510)
PTPN2 [cytosol]
(R-HSA-997292)
PTPN2 [nucleoplasm]
(R-HSA-9008891)
0.527
2
UniProt:O75845 SC5D
1
SC5D [endoplasmic reticulum membrane]
(R-HSA-195662)
0.527
2
UniProt:Q9H2C2 ARV1
1
ARV1 [endoplasmic reticulum membrane]
(R-HSA-5216144)
0.527
2
UniProt:Q15800 MSMO1
1
MSMO1 [endoplasmic reticulum membrane]
(R-HSA-194648)
0.527
2
UniProt:Q9NXB9 ELOVL2
1
ELOVL2 [endoplasmic reticulum membrane]
(R-HSA-548677)
0.527
2
UniProt:Q9UBV7 B4GALT7
4
B4GALT7 A186D [Golgi membrane]
(R-HSA-3621785)
B4GALT7 L206P [Golgi membrane]
(R-HSA-3621790)
B4GALT7 R270C [Golgi membrane]
(R-HSA-3621734)
B4GALT7 [Golgi membrane]
(R-HSA-1889950)
0.527
2
UniProt:Q8IVQ6 ZDHHC21
1
ZDHHC21 [Golgi membrane]
(R-HSA-203757)
0.527
2
UniProt:Q9H5K3 POMK
1
POMK [endoplasmic reticulum membrane]
(R-HSA-8879120)
0.527
2
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.527
2
UniProt:Q6ZMG9 CERS6
1
CERS6 [endoplasmic reticulum membrane]
(R-HSA-428145)
0.527
2
UniProt:Q3ZAQ7 VMA21
0.527
2
UniProt:Q96NT0 CCDC115
1
CCDC115 [endoplasmic reticulum membrane]
(R-HSA-9714329)
0.527
2
UniProt:Q8N6M3 FITM2
1
FITM2 [endoplasmic reticulum membrane]
(R-HSA-8857678)
0.527
2
UniProt:Q96MV1 TLCD4
0.527
2
UniProt:Q8N5B7 CERS5
1
CERS5 [endoplasmic reticulum membrane]
(R-HSA-428168)
0.527
2
UniProt:O95159 ZFPL1
0.527
2
UniProt:O43808 SLC25A17
2
SLC25A17 [cytosol]
(R-HSA-9603781)
SLC25A17 [peroxisomal membrane]
(R-HSA-389642)
0.527
2
UniProt:Q8IUH4 ZDH13
0.527
2
UniProt:Q92633 LPAR1
1
LPAR1 [plasma membrane]
(R-HSA-419354)
0.527
2
UniProt:Q8NBX0 SCCPDH
2
SCCPDH [extracellular region]
(R-HSA-8862997)
SCCPDH [platelet alpha granule lumen]
(R-HSA-8862982)
0.527
2
UniProt:Q96MH6 DIESL
0.527
2
UniProt:Q6Y1H2 HACD2
1
PTPLB [endoplasmic reticulum membrane]
(R-HSA-5676075)
0.527
2
UniProt:O43674 NDUFB5
1
NDUFB5 [mitochondrial inner membrane]
(R-HSA-163944)
0.527
2
UniProt:Q8NHS3 MFSD8
0.527
2
UniProt:O43913 ORC5
1
ORC5 [nucleoplasm]
(R-HSA-68516)
0.527
2
UniProt:O60779 SLC19A2
1
SLC19A2 [plasma membrane]
(R-HSA-199636)
0.527
2
UniProt:Q00765 REEP5
0.527
2
UniProt:Q8TBA6 GOLGA5
2
GOLGA5 [transport vesicle]
(R-HSA-8847517)
GOLGA5 [Golgi membrane]
(R-HSA-8847514)
0.527
2
UniProt:A0PK00 T120B
0.527
2
UniProt:O75110 ATP9A
1
ATP9A [plasma membrane]
(R-HSA-939754)
0.527
2
UniProt:Q9Y375 NDUFAF1
1
NDUFAF1 [mitochondrial inner membrane]
(R-HSA-5689050)
0.527
2
UniProt:Q7Z7E8 UBE2Q1
1
UBE2Q1 [cytosol]
(R-HSA-947629)
0.527
2
UniProt:P24539 ATP5PB
1
ATP5PB [mitochondrial inner membrane]
(R-HSA-164537)
0.527
2
UniProt:Q9NRZ5 AGPAT4
1
AGPAT4 [endoplasmic reticulum membrane]
(R-HSA-61809)
0.527
2
UniProt:O95858 TSPAN15
2
TSPAN15 [plasma membrane]
(R-HSA-9010043)
TSPAN15 [endoplasmic reticulum lumen]
(R-HSA-9010117)
0.527
2
UniProt:A6NFQ2 TCAF2
0.527
2
UniProt:O75907 DGAT1
3
DGAT1 [plasma membrane]
(R-HSA-6806313)
DGAT1 [specific granule membrane]
(R-HSA-6799564)
DGAT1 [endoplasmic reticulum membrane]
(R-HSA-53579)
0.527
2
UniProt:O94886 TMEM63A
3
TMEM63A [tertiary granule membrane]
(R-HSA-6800945)
TMEM63A [plasma membrane]
(R-HSA-6800445)
TMEM63A [specific granule membrane]
(R-HSA-6799721)
0.527
2
UniProt:Q8WUY8 NAT14
0.527
2
UniProt:Q8N8J7 F241A
0.527
2
UniProt:Q9HBH5 RDH14
1
RDH14 [endoplasmic reticulum membrane]
(R-HSA-2980933)
0.527
2
UniProt:Q92968 PEX13
2
PEX13 [cytosol]
(R-HSA-9603795)
PEX13 [peroxisomal membrane]
(R-HSA-452790)
0.527
2
UniProt:P61019 RAB2A
3
GGC-RAB2A [cytosol]
(R-HSA-8873963)
RAB2A [cytosol]
(R-HSA-8873716)
RAB2A [Golgi membrane]
(R-HSA-2422386)
0.527
2
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