Reactome | C5AR2 [plasma membrane]

C5AR2 [plasma membrane]

Stable Identifier

R-HSA-964798

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

GPR77, C5a anaphylatoxin chemotactic receptor C5L2, C5ARL_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9P296 C5AR2

Gene Names

C5AR2, C5L2, GPR77

Chain

chain:1-337

Reference Genes

BioGPS Gene:27202 C5AR2

COSMIC (genes):C5AR2 C5AR2

CTD Gene:27202 C5AR2

dbSNP Gene:27202 C5AR2

ENSEMBL:ENSG00000134830 C5AR2

HGNC:4527 C5AR2

KEGG:hsa:27202 C5AR2

Monarch:27202 C5AR2

NCBI Gene:27202 C5AR2

OMIM:609949 C5AR2

UCSC:Q9P296 C5AR2

Reference Transcript

Other Identifiers

11737869_at

16863593

221149_PM_at

221149_at

27202

3837127

3837128

3837270

3837271

3837272

3837274

3837275

3837277

3837278

3837279

3837280

3837281

3837282

3837326

79700_at

8029914

89539_at

A_23_P164943

A_33_P3223002

GE552756

GE555686

GE558290

GO:0002376

GO:0002430

GO:0002682

GO:0004875

GO:0004878

GO:0004930

GO:0005515

GO:0005886

GO:0006935

GO:0006954

GO:0007186

GO:0007200

GO:0007204

GO:0009925

GO:0016020

GO:0032677

GO:0032715

GO:0032720

GO:0038178

GO:0045177

GO:0060089

GO:0090024

HMNXSV003018957

ILMN_1669317

ILMN_1907649

PH_hs_0014597

TC19000677.hg

g8923872_3p_at

p8791

Participates

as a component of

C5AR2:C5AR2 ligands [plasma membrane] (Homo sapiens)

as an input of

C5AR2 binds anaphylatoxins and thier desArginated derivatives (Homo sapiens)

Inferred To

C5ar2 [plasma membrane] (Mus musculus)

C5ar2 [plasma membrane] (Rattus norvegicus)

C5AR2 [plasma membrane] (Bos taurus)

C5AR2 [plasma membrane] (Canis familiaris)

C5AR2 [plasma membrane] (Gallus gallus)

C5AR2 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001258679.1, NP_060955.1, XP_011525038.1, NP_001258678.1

Guide to Pharmacology - Targets

OpenTargets

ENSG00000134830

ENSEMBL

ENST00000600626, ENST00000595464, ENSP00000472620, ENSP00000471184

HPA

ENSG00000134830-C5AR2

PRO

Q9P296

Pharos - Targets

Q9P296

GlyGen

Q9P296

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHG0 DCDC2			0.556	3
UniProt:O75911 DHRS3	2	DHRS3 [endoplasmic reticulum membrane] (R-HSA-5419172) DHRS3 [photoreceptor outer segment membrane] (R-HSA-2980986)	0.527	2
UniProt:P17706 PTPN2	3	p-PTPN2 [cytosol] (R-HSA-9836510) PTPN2 [cytosol] (R-HSA-997292) PTPN2 [nucleoplasm] (R-HSA-9008891)	0.527	2
UniProt:Q6ICH7 ASPH2			0.527	2
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.527	2
UniProt:P56962 STX17	1	STX17 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6807769)	0.527	2
UniProt:Q96CN4 EVI5L			0.527	2
UniProt:O43542 XRCC3	1	XRCC3 [nucleoplasm] (R-HSA-5685303)	0.527	2
UniProt:Q9BV23 ABHD6	1	ABHD6 [plasma membrane] (R-HSA-5694483)	0.527	2
UniProt:O14981 BTAF1			0.527	2
UniProt:Q9H7F0 AT133			0.527	2
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.527	2
UniProt:Q8N442 GUF1			0.527	2
UniProt:Q68DH5 LMBD2			0.527	2
UniProt:Q6DD88 ATLA3			0.527	2
UniProt:Q9H4A5 GLP3L			0.527	2
UniProt:Q8NEC7 GSTCD			0.527	2
UniProt:P09601 HMOX1	4	HMOX1 [cytosol] (R-HSA-9609901) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [nucleoplasm] (R-HSA-9708567)	0.527	2
UniProt:O60476 MAN1A2	2	MAN1A2 [transport vesicle] (R-HSA-8847486) MAN1A2 [Golgi membrane] (R-HSA-964747)	0.527	2
UniProt:Q9H4A6 GOLP3			0.527	2
UniProt:O14976 GAK	3	GAK [cytosol] (R-HSA-8868619) GAK [Golgi membrane] (R-HSA-434340) GAK [cytoplasmic vesicle membrane] (R-HSA-434203)	0.527	2
UniProt:Q96E22 NUS1	1	NUS1 [endoplasmic reticulum membrane] (R-HSA-6806946)	0.527	2
UniProt:Q96RD7 PANX1	1	PANX1 [plasma membrane] (R-HSA-375344)	0.527	2
UniProt:Q9BSJ2 TUBGCP2	1	TUBGCP2 [cytosol] (R-HSA-379275)	0.527	2
UniProt:O75915 ARL6IP5	1	ARL6IP5 [cytosol] (R-HSA-2980942)	0.527	2
UniProt:Q9Y666 SLC12A7	1	SLC12A7 [plasma membrane] (R-HSA-426164)	0.527	2
UniProt:P24468 NR2F2	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.527	2
UniProt:Q9BXP2 S12A9			0.527	2
UniProt:Q8NDZ2 SIMC1			0.527	2
UniProt:P10588 NR2F6	1	NR2F6 [nucleoplasm] (R-HSA-376279)	0.527	2
UniProt:P33981 TTK			0.527	2

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