Reactome | 3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]

3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-2023553

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

4-Hyp 5-Gal-Hyl collagen alpha-1(V) propeptide, CO5A1_HUMAN, COL5A1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P20908 COL5A1

Gene Names

COL5A1

Chain

signal peptide:1-37, chain:38-1605, propeptide:1606-1838

Reference Genes

BioGPS Gene:1289 COL5A1

COSMIC (genes):COL5A1 COL5A1

CTD Gene:1289 COL5A1

dbSNP Gene:1289 COL5A1

ENSEMBL:ENSG00000130635 COL5A1

HGNC:2209 COL5A1

KEGG:hsa:1289 COL5A1

Monarch:1289 COL5A1

NCBI Gene:1289 COL5A1

OMIM:120215 COL5A1

UCSC:P20908 COL5A1

Reference Transcript

RefSeq:NM_000093.4 COL5A1

Other Identifiers

11717272_at

11717273_at

11717274_s_at

11717275_s_at

1289

17090957

203325_PM_s_at

203325_s_at

212488_PM_at

212488_at

212489_PM_at

212489_at

3193484

3193485

3193489

3193497

3193498

3193499

3193500

3193505

3193506

3193510

3193519

3193520

3193523

3193524

3193525

3193526

3193527

3193528

3193533

3193534

3193535

3193536

3193538

3193539

3193541

3193542

3193543

3193546

3193547

3193548

3193549

3193550

3193552

3193553

3193558

3193559

3193561

3193563

3193564

3193567

3193568

3193569

3193570

3193572

3193581

3193582

3193584

3193585

3193586

3193587

3193589

3193590

3193591

3193592

3193593

3193594

3193597

3193599

3193600

3193601

3193602

3193605

3193606

3193607

3193608

3193610

3193611

3193613

3193615

3193616

3193619

3193620

3193624

3193625

3193626

3193627

3193628

3193629

3193630

3193632

8159142

A_14_P116738

A_14_P118684

A_23_P158593

A_33_P3383351

A_33_P3629678

D90279_s_at

GE80890

GO:0001568

GO:0003007

GO:0005178

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005581

GO:0005588

GO:0005604

GO:0005615

GO:0005788

GO:0007155

GO:0008201

GO:0016477

GO:0030020

GO:0030198

GO:0030199

GO:0030312

GO:0031012

GO:0032964

GO:0035313

GO:0035989

GO:0043394

GO:0043588

GO:0045112

GO:0046872

GO:0048407

GO:0048592

GO:0048856

GO:0048870

GO:0051128

GO:0062023

GO:0097435

GO:1903225

HMNXSV003023043

HMNXSV003047021

Hs.146428.0.S2_3p_a_at

Hs.146428.2.A1_3p_at

Hs.146428.2.A2_3p_at

ILMN_1706505

PH_hs_0025290

TC09000787.hg

Participates

as a candidate of

4-Hyp 5-Gal-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)

as a member of

Alpha-1(V) propeptides [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]

GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]

GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]

COL5A1(38-1838) [endoplasmic reticulum lumen]

3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]

3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]

5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]

3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region]

COL5A1(38-1838) [extracellular region]

3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region]

3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region]

3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region]

GalHyl-COL5A1(38-1838) [extracellular region]

5Hyl-COL5A1(38-1838) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [extracellular region]

GlcGalHyl-COL5A1(38-1838) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region]

3x4Hyp-COL5A1(38-1838) [extracellular region]

GalHyl-COL5A1(?-1838) [extracellular region]

3x4Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL5A1(?-1838) [extracellular region]

GlcGalHyl-COL5A1(?-1838) [extracellular region]

3x4Hyp-5Hyl-COL5A1(?-1838) [extracellular region]

3x4Hyp-COL5A1(?-1838) [extracellular region]

3x4Hyp-3Hyp-COL5A1(?-1838) [extracellular region]

Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region]

4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region]

4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region]

3,4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region]

3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region]

3,4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region]

4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region]

5-Gal-Hyl collagen alpha-1(V) chain [extracellular region]

4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region]

Collagen alpha-1(V) chain [extracellular region]

5-hydroxylysyl collagen alpha-1(V) chain [extracellular region]

3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL5A1(?-?) [extracellular region]

4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]

4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region]

3x4Hyp-3Hyp-COL5A1(?-?) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL5A1(?-?) [extracellular region]

3x4Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region]

3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]

GlcGalHyl-COL5A1(?-?) [extracellular region]

5Hyl-COL5A1(?-?) [extracellular region]

3x4Hyp-GalHyl-COL5A1(?-?) [extracellular region]

5-hydroxylysyl collagen alpha-1(V) chain C-term fragment [extracellular region]

4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]

GalHyl-COL5A1(?-?) [extracellular region]

3x4Hyp-5Hyl-COL5A1(?-?) [extracellular region]

3x4Hyp-COL5A1(?-?) [extracellular region]

3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]

3,4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region]

Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]

4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]

5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region]

3,4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]

COL5A1(?-?) [extracellular region]

Collagen alpha-1(V) chain C-term fragment [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region]

COL5A1(?-1838) [extracellular region]

3x4Hyp-GalHyl-COL5A1(?-1838) [extracellular region]

5Hyl-COL5A1(?-1838) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL5A1(?-1838) [extracellular region]

Inferred To

3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Gallus gallus)

COL5A1 [endoplasmic reticulum lumen] (Bos taurus)

COL5A1 [endoplasmic reticulum lumen] (Canis familiaris)

COL5A1 [endoplasmic reticulum lumen] (Sus scrofa)

col5a1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Col5a1 [endoplasmic reticulum lumen] (Mus musculus)

Col5a1 [endoplasmic reticulum lumen] (Rattus norvegicus)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

NP_000084.3

OpenTargets

ENSG00000130635

ENSEMBL

ENSP00000360882, ENST00000371820, ENSP00000360885, ENST00000371817

HPA

ENSG00000130635-COL5A1

PRO

P20908

Pharos - Targets

P20908

GlyGen

P20908

Orphanet

COL5A1

PDB

7Y37

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08253 MMP2	5	MMP2(110-660) [extracellular region] (R-HSA-381456) MMP2(30-660) [extracellular region] (R-HSA-1604364) MMP2(67-660) [extracellular region] (R-HSA-1604345) MMP2(30-66) [extracellular region] (R-HSA-1604347) MMP2(67-109) [extracellular region] (R-HSA-1604371)	0.716	4
UniProt:P17706 PTPN2	3	p-PTPN2 [cytosol] (R-HSA-9836510) PTPN2 [cytosol] (R-HSA-997292) PTPN2 [nucleoplasm] (R-HSA-9008891)	0.589	2
UniProt:P14780 MMP9	8	MMP9(107-707) [extracellular region] (R-HSA-668812) MMP9(20-707) [extracellular region] (R-HSA-1604376) MMP9(20-106) [extracellular region] (R-HSA-1604713) MMP9(20-59) [extracellular region] (R-HSA-1604685) MMP9(60-707) [extracellular region] (R-HSA-1604726) MMP9(60-106) [extracellular region] (R-HSA-1604699) MMP9 [tertiary granule lumen] (R-HSA-6800181) MMP9 [ficolin-1-rich granule lumen] (R-HSA-6800973)	0.527	2
UniProt:P24821 TNC	3	TNC [endoplasmic reticulum lumen] (R-HSA-8956722) p-TNC [endoplasmic reticulum lumen] (R-HSA-8956912) TNC [extracellular region] (R-HSA-215968)	0.508	2
UniProt:P01033 TIMP1	4	TIMP1 [platelet alpha granule lumen] (R-HSA-349745) p-TIMP1 [endoplasmic reticulum lumen] (R-HSA-8957082) TIMP1 [endoplasmic reticulum lumen] (R-HSA-8956691) TIMP1 [extracellular region] (R-HSA-349743)	0.508	2

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