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3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-2022948
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
4-Hyp 5-Hyl collagen alpha-1(V) propeptide, CO5A1_HUMAN, COL5A1
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Collagen biosynthesis and modifying enzymes (Homo sapiens)
COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Homo sapiens)
COLGALT1,COLGALT2:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
Collagen chain trimerization (Homo sapiens)
Association of procollagen type V (Homo sapiens)
Alpha-1(V) propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
C-linked procollagen type V trimers [endoplasmic reticulum lumen] (Homo sapiens)
C-linked procollagen alpha-1(V)X2 alpha-2(V) trimer [endoplasmic reticulum lumen] (Homo sapiens)
Alpha-1(V) propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
C-linked procollagen alpha-1-3(V) propeptide trimer [endoplasmic reticulum lumen] (Homo sapiens)
Alpha-1(V) propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Homo sapiens)
PLOD3:Fe2+ dimer:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum membrane] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2 (Homo sapiens)
COLGALT1,COLGALT2:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Homo sapiens)
Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
PLOD3 binds Lysyl hydroxylated collagen propeptides (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
PLOD3:Fe2+ dimer:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum membrane] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Homo sapiens)
Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen triple helix formation (Homo sapiens)
Collagen and procollagen triple helices:Serpin H1 [endoplasmic reticulum lumen] (Homo sapiens)
Collagen and procollagen triple helices [endoplasmic reticulum lumen] (Homo sapiens)
Fibrillar procollagen triple helices [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen type V [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen alpha-1(V)X2 alpha-2(V) [endoplasmic reticulum lumen] (Homo sapiens)
Alpha-1(V) propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen alpha-1-3(V) [endoplasmic reticulum lumen] (Homo sapiens)
Alpha-1(V) propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen C-linked trimers [endoplasmic reticulum lumen] (Homo sapiens)
C-linked procollagen type V trimers [endoplasmic reticulum lumen] (Homo sapiens)
C-linked procollagen alpha-1(V)X2 alpha-2(V) trimer [endoplasmic reticulum lumen] (Homo sapiens)
Alpha-1(V) propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
C-linked procollagen alpha-1-3(V) propeptide trimer [endoplasmic reticulum lumen] (Homo sapiens)
Alpha-1(V) propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
Secretion of collagens (Homo sapiens)
Collagens and tropocollagens:Serpin H1 [endoplasmic reticulum lumen] (Homo sapiens)
Collagens and tropocollagens [endoplasmic reticulum lumen] (Homo sapiens)
Fibrillar procollagen triple helices [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen type V [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen alpha-1(V)X2 alpha-2(V) [endoplasmic reticulum lumen] (Homo sapiens)
Alpha-1(V) propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen alpha-1-3(V) [endoplasmic reticulum lumen] (Homo sapiens)
Alpha-1(V) propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20908 COL5A1
Gene Names
COL5A1
Chain
signal peptide:1-37, chain:38-1605, propeptide:1606-1838
Reference Genes
BioGPS Gene:1289 COL5A1
COSMIC (genes):COL5A1 COL5A1
CTD Gene:1289 COL5A1
dbSNP Gene:1289 COL5A1
ENSEMBL:ENSG00000130635 COL5A1
ENSEMBL_homo_sapiens_GENE:ENSG00000130635.17 COL5A1
HGNC:2209 COL5A1
KEGG Gene (Homo sapiens):1289 COL5A1
Monarch:1289 COL5A1
NCBI Gene:1289 COL5A1
OMIM:120215 COL5A1
UCSC:P20908 COL5A1
Reference Transcript
RefSeq:NM_000093.4 COL5A1
Other Identifiers
11717272_at
11717273_at
11717274_s_at
11717275_s_at
1289
17090957
203325_PM_s_at
203325_s_at
212488_PM_at
212488_at
212489_PM_at
212489_at
3193484
3193485
3193497
3193498
3193505
3193506
3193519
3193520
3193523
3193524
3193525
3193527
3193528
3193533
3193534
3193535
3193536
3193538
3193539
3193541
3193542
3193543
3193546
3193547
3193548
3193549
3193550
3193552
3193553
3193558
3193559
3193561
3193563
3193564
3193567
3193568
3193569
3193570
3193572
3193581
3193582
3193584
3193585
3193586
3193587
3193589
3193590
3193591
3193592
3193593
3193594
3193597
3193599
3193600
3193601
3193602
3193605
3193606
3193607
3193608
3193610
3193611
3193613
3193615
3193616
3193619
3193620
3193624
3193625
3193626
3193627
3193628
3193629
3193630
3193632
8159142
A_14_P116738
A_14_P118684
A_23_P158593
A_33_P3629678
D90279_s_at
GE80890
GO:0001568
GO:0003007
GO:0005178
GO:0005198
GO:0005201
GO:0005515
GO:0005576
GO:0005581
GO:0005588
GO:0005604
GO:0005615
GO:0005783
GO:0005788
GO:0007155
GO:0008201
GO:0016477
GO:0030020
GO:0030154
GO:0030198
GO:0030199
GO:0030312
GO:0031012
GO:0032964
GO:0035313
GO:0035989
GO:0042060
GO:0043226
GO:0043394
GO:0043588
GO:0045112
GO:0046872
GO:0048407
GO:0048592
GO:0048856
GO:0048870
GO:0051128
GO:0061024
GO:0062023
GO:0097435
GO:1903225
HMNXSV003023043
Hs.146428.0.S2_3p_a_at
Hs.146428.2.A1_3p_at
Hs.146428.2.A2_3p_at
ILMN_1706505
PH_hs_0025290
TC09000787.hg
Participates
as a member of
Alpha-1(V) propeptides [endoplasmic reticulum lumen] (Homo sapiens)
as a candidate of
4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
COL5A1(38-1838) [endoplasmic reticulum lumen]
3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region]
COL5A1(38-1838) [extracellular region]
3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region]
3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region]
3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region]
GalHyl-COL5A1(38-1838) [extracellular region]
5Hyl-COL5A1(38-1838) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [extracellular region]
GlcGalHyl-COL5A1(38-1838) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region]
3x4Hyp-COL5A1(38-1838) [extracellular region]
GalHyl-COL5A1(?-1838) [extracellular region]
3x4Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL5A1(?-1838) [extracellular region]
GlcGalHyl-COL5A1(?-1838) [extracellular region]
3x4Hyp-5Hyl-COL5A1(?-1838) [extracellular region]
3x4Hyp-COL5A1(?-1838) [extracellular region]
3x4Hyp-3Hyp-COL5A1(?-1838) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL5A1(?-1838) [extracellular region]
5Hyl-COL5A1(?-1838) [extracellular region]
3x4Hyp-GalHyl-COL5A1(?-1838) [extracellular region]
COL5A1(?-1838) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region]
Collagen alpha-1(V) chain C-term fragment [extracellular region]
COL5A1(?-?) [extracellular region]
3,4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region]
5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
3,4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region]
3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
3x4Hyp-COL5A1(?-?) [extracellular region]
3x4Hyp-5Hyl-COL5A1(?-?) [extracellular region]
GalHyl-COL5A1(?-?) [extracellular region]
4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
5-hydroxylysyl collagen alpha-1(V) chain C-term fragment [extracellular region]
3x4Hyp-GalHyl-COL5A1(?-?) [extracellular region]
5Hyl-COL5A1(?-?) [extracellular region]
GlcGalHyl-COL5A1(?-?) [extracellular region]
3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
3x4Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL5A1(?-?) [extracellular region]
Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region]
4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
3,4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region]
3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
3,4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region]
4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region]
5-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
Collagen alpha-1(V) chain [extracellular region]
5-hydroxylysyl collagen alpha-1(V) chain [extracellular region]
3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL5A1(?-?) [extracellular region]
4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region]
3x4Hyp-3Hyp-COL5A1(?-?) [extracellular region]
Inferred To
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(Gallus gallus)
COL5A1 [endoplasmic reticulum lumen]
(Bos taurus)
COL5A1 [endoplasmic reticulum lumen]
(Canis familiaris)
COL5A1 [endoplasmic reticulum lumen]
(Sus scrofa)
col5a1 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Col5a1 [endoplasmic reticulum lumen]
(Mus musculus)
Col5a1 [endoplasmic reticulum lumen]
(Rattus norvegicus)
Modified Residues
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,5R)-5-hydroxylysine at unknown position
PsiMod Name
(2S,5R)-5-hydroxylysine
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to 5-hydroxy-L-lysine.
Cross References
RefSeq
NP_000084.3
OpenTargets
ENSG00000130635
HPA
ENSG00000130635-COL5A1
GeneCards
P20908
Ensembl
ENSP00000360882
,
ENST00000371817
,
ENSG00000130635
,
ENST00000371820
,
ENSP00000360885
PRO
P20908
Pharos - Targets
P20908
Orphanet
15776
PDB
7Y37
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08253 MMP2
5
MMP2(67-109) [extracellular region]
(R-HSA-1604371)
MMP2(67-660) [extracellular region]
(R-HSA-1604345)
MMP2(30-66) [extracellular region]
(R-HSA-1604347)
MMP2(30-660) [extracellular region]
(R-HSA-1604364)
MMP2(110-660) [extracellular region]
(R-HSA-381456)
0.716
4
UniProt:P17706 PTPN2
3
p-PTPN2 [cytosol]
(R-HSA-9836510)
PTPN2 [nucleoplasm]
(R-HSA-9008891)
PTPN2 [cytosol]
(R-HSA-997292)
0.589
2
UniProt:P14780 MMP9
8
MMP9 [ficolin-1-rich granule lumen]
(R-HSA-6800973)
MMP9 [tertiary granule lumen]
(R-HSA-6800181)
MMP9(60-106) [extracellular region]
(R-HSA-1604699)
MMP9(60-707) [extracellular region]
(R-HSA-1604726)
MMP9(20-59) [extracellular region]
(R-HSA-1604685)
MMP9(20-106) [extracellular region]
(R-HSA-1604713)
MMP9(20-707) [extracellular region]
(R-HSA-1604376)
MMP9(107-707) [extracellular region]
(R-HSA-668812)
0.527
2
UniProt:P01033 TIMP1
4
TIMP1 [platelet alpha granule lumen]
(R-HSA-349745)
TIMP1 [extracellular region]
(R-HSA-349743)
p-TIMP1 [endoplasmic reticulum lumen]
(R-HSA-8957082)
TIMP1 [endoplasmic reticulum lumen]
(R-HSA-8956691)
0.508
2
UniProt:P24821 TNC
3
p-TNC [endoplasmic reticulum lumen]
(R-HSA-8956912)
TNC [endoplasmic reticulum lumen]
(R-HSA-8956722)
TNC [extracellular region]
(R-HSA-215968)
0.508
2
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