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ITGA1 [plasma membrane]
Stable Identifier
R-HSA-215939
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Integrin alpha-1, ITA1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
CHL1 interactions (Homo sapiens)
CHL1 interacts with beta1 integrins (Homo sapiens)
CHL1:alpha1beta1/alpha2beta1 integrins [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Other semaphorin interactions (Homo sapiens)
SEMA7A binds to integrin alpha1beta1 (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
SEMA7A:Integrin alpha1beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins) (Homo sapiens)
Agrin:Integrin alphaVbeta1 (other beta1) [plasma membrane] (Homo sapiens)
Integrins alphaVbeta1 (other beta 1) [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Integrins alphaVbeta1 (other beta 1) [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Arresten binds integrin alpha1beta1 (Homo sapiens)
Arresten:Integrin alpha1beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Integrins alpha1beta1, alpha2beta1:Collagen type I fibril:Mg2+ [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Collagen type II binds integrin alpha2beta1, alpha1beta1, alpha11beta1 (Homo sapiens)
Collagen type II fibril:Integrins alpha2beta1, alpha1beta1, alpha11beta1 [plasma membrane] (Homo sapiens)
Integrins alpha1beta1, alpha2beta1, alpha11beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Integrins alpha1beta1, alpha2beta1, alpha11beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Integrins alpha1beta1, alpha2beta1:Collagen type IV networks:Mg2+ [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Collagen type XIII binds Integrin alpha1beta1 (Homo sapiens)
Collagen type XIII:Integrin alpha1beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens)
Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Laminin interactions (Homo sapiens)
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1 bind laminin-111 (Homo sapiens)
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1, alphaVbeta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1, alphaVbeta1:Laminin-111 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1, alphaVbeta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet Adhesion to exposed collagen (Homo sapiens)
Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Integrins alpha1beta1, alpha2beta1:Collagen type I fibril:Mg2+ [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Calcium Binds Caldesmon (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
ITGA1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P56199 ITGA1
Gene Names
ITGA1
Chain
signal peptide:1-28, chain:29-1179
Reference Genes
BioGPS Gene:3672 ITGA1
COSMIC (genes):ITGA1 ITGA1
CTD Gene:3672 ITGA1
dbSNP Gene:3672 ITGA1
ENSEMBL:ENSG00000213949 ITGA1
HGNC:6134 ITGA1
KEGG:hsa:3672 ITGA1
Monarch:3672 ITGA1
NCBI Gene:3672 ITGA1
OMIM:192968 ITGA1
UCSC:P56199 ITGA1
Reference Transcript
RefSeq:NM_181501.1 ITGA1
Other Identifiers
11737127_a_at
120_at
1560359_PM_at
1560359_at
16984646
214660_PM_at
214660_at
226731_PM_at
226731_at
2809129
2809130
2809154
2809161
2809170
2809172
2809173
2809175
2809180
2809181
2809182
2809183
2809184
2809187
2809188
2809189
2809190
2809191
2809192
2809193
2809196
2809197
2809199
2809200
2809202
2809207
2809208
2809209
2809211
2809212
2809213
2809214
2809215
2809218
2809219
2809220
2809221
2809222
2809224
2809225
2809226
2809227
2809228
2809229
2809230
2809231
2809232
2809233
2809234
2809239
2809240
2809242
2809244
3672
37484_at
44710_at
45072_r_at
45200_at
8105229
A_14_P117628
A_23_P256334
A_33_P3353791
GE59949
GE900696
GO:0001669
GO:0002376
GO:0003013
GO:0005102
GO:0005178
GO:0005515
GO:0005518
GO:0005886
GO:0005925
GO:0007155
GO:0007160
GO:0007229
GO:0008285
GO:0008305
GO:0009897
GO:0009986
GO:0016020
GO:0019903
GO:0030593
GO:0031410
GO:0032516
GO:0033627
GO:0034665
GO:0042059
GO:0042311
GO:0043204
GO:0043226
GO:0043410
GO:0043525
GO:0045123
GO:0045178
GO:0046872
GO:0048812
GO:0048870
GO:0060326
GO:0070062
GO:0098609
GO:0098631
GO:0098639
HMNXSV003010833
Hs.116774.0.S1_3p_at
Hs.184411.5.S1_3p_at
Hs2.420404.1.S1_3p_at
ILMN_1802411
ILMN_1849698
PH_hs_0003450
PH_hs_0036014
TC05002373.hg
TC05003439.hg
X68742_at
p26306
Participates
as a component of
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
ITGA1:ITGB1 [plasma membrane] (Homo sapiens)
Inferred To
Integrin alpha-1 [plasma membrane]
(Mus musculus)
ITGA1 [plasma membrane]
(Bos taurus)
ITGA1 [plasma membrane]
(Canis familiaris)
ITGA1 [plasma membrane]
(Gallus gallus)
ITGA1 [plasma membrane]
(Rattus norvegicus)
ITGA1 [plasma membrane]
(Sus scrofa)
if [plasma membrane]
(Drosophila melanogaster)
pat-2 [plasma membrane]
(Caenorhabditis elegans)
itga1 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_852478.1
Guide to Pharmacology - Targets
2437
ENSEMBL
ENST00000282588
,
ENSP00000282588
OpenTargets
ENSG00000213949
HPA
ENSG00000213949-ITGA1
ZINC - Substances
ITA1_HUMAN
ZINC target
P56199
PRO
P56199
Pharos - Targets
P56199
GlyGen
P56199
PDB
1QCY
,
2L8S
,
1QC5
,
1PT6
,
4A0Q
,
2M32
,
5HGJ
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17931 LGALS3
3
LGALS3 [ficolin-1-rich granule membrane]
(R-HSA-6803307)
LGALS3 [plasma membrane]
(R-HSA-879445)
LGALS3 [secretory granule membrane]
(R-HSA-6803327)
0.527
3
UniProt:P17706 PTPN2
3
p-PTPN2 [cytosol]
(R-HSA-9836510)
PTPN2 [cytosol]
(R-HSA-997292)
PTPN2 [nucleoplasm]
(R-HSA-9008891)
0.463
2
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