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p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm]
Stable Identifier
R-HSA-9920661
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S90-ARNTL:p-T451,T461-CLOCK
Locations in the PathwayBrowser
Expand all
Circadian clock (Homo sapiens)
BMAL1:CLOCK,NPAS2 activates circadian expression (Homo sapiens)
Expression of AVP (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:AVP gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Expression of CCRN4L (NOCTURNIN) (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CCRN4L gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Expression of DEC1 (BHLHE40, BHLHB2) (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:BHLHE40 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Expression of DEC2 (BHLHE41, BHLHB3) (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:BHLHE41 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Expression of KLF15 (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:KLF15 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Expression of NAMPT (NamPRT, PBEF, Visfatin) (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:NAMPT gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Expression of PPARA (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:PPARA gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Expression of SERPINE1 (PAI-1) (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:SERPINE1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds AVP gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:AVP gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds BHLHE40 gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:BHLHE40 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds BHLHE41 (DEC2) gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:BHLHE41 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds CCRN4L (NOCTURNIN) gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CCRN4L gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds KLF15 gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:KLF15 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds NAMPT gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:NAMPT gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds PPARA gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:PPARA gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds SERPINE1 gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:SERPINE1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes (Homo sapiens)
Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Cryptochrome-2 (CRY2) (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of DBP (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:DBP gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Period-3 (PER3) (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of RORC (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:RORC gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Phosphorylated BMAL1:CLOCK positively regulates expression of NR1D1 (REV-ERBA) (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Phosphorylated BMAL1:CLOCK positively regulates expression of RORA (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:RORA gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-90-BMAL1:p-T451,T461-CLOCK and coactivators bind the DBP gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:DBP gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the CRY2 gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the PER3 gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the RORC gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:RORC gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds the RORA gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:RORA gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters (Homo sapiens)
p-T451,T461-CLOCK is phosphorylated on serines-440,441,446 (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER2 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:KMT2A:CRY1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:RORA gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of PPARA (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:PPARA gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] (Homo sapiens)
Participants
components
p-S90-BMAL1 [nucleoplasm]
(Homo sapiens)
p-T451,T461-CLOCK [nucleoplasm]
(Homo sapiens)
Participates
as a component of
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:KMT2A:CRY1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER2 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:BHLHE41 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CCRN4L gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:BHLHE40 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:AVP gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:KLF15 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:SERPINE1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:DBP gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:NAMPT gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:RORC gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:RORA gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:PPARA gene [nucleoplasm] (Homo sapiens)
as an input of
p-S90-BMAL1:p-T451,T461-CLOCK binds BHLHE41 (DEC2) gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds CCRN4L (NOCTURNIN) gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds BHLHE40 gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds AVP gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds KLF15 gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds SERPINE1 gene (Homo sapiens)
p-90-BMAL1:p-T451,T461-CLOCK and coactivators bind the DBP gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the PER3 gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the CRY2 gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds NAMPT gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the RORC gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds the RORA gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK binds PPARA gene (Homo sapiens)
as an output of
p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus (Homo sapiens)
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