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p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm]
Stable Identifier
R-HSA-9922981
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S90-BMAL1:p-T451,T461-CLOCK:CBP:MLL1:NR1D1 gene
Locations in the PathwayBrowser
Expand all
Circadian clock (Homo sapiens)
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes (Homo sapiens)
Phosphorylated BMAL1:CLOCK positively regulates expression of NR1D1 (REV-ERBA) (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters (Homo sapiens)
p-T451,T461-CLOCK is phosphorylated on serines-440,441,446 (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
Participants
components
CREBBP [nucleoplasm]
(Homo sapiens)
KMT2A [nucleoplasm]
(Homo sapiens)
NR1D1 gene [nucleoplasm]
(Homo sapiens)
x 2
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm]
(Homo sapiens)
Participates
as a member of
p-S90-BMAL1:p-T451,T461-CLOCK:target gene [nucleoplasm] (Homo sapiens)
as an output of
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene (Homo sapiens)
This entity regulates
Positively
Phosphorylated BMAL1:CLOCK positively regulates expression of NR1D1 (REV-ERBA)
(Homo sapiens)
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