p-BMAL1:p-CLOCK,NPAS2 binds PPARA gene

Stable Identifier
R-HSA-5663156
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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p-BMAL1:p-CLOCK,NPAS2 binds PPARA gene
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As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) heterodimers bind E-boxes in the second intron of the PPARA gene and activate transcription of PPARA.

Literature References
PubMed ID Title Journal Year
15500444 CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor alpha (PPARalpha) in mice

Oishi, K, Shirai, H, Ishida, N

Biochem J 2005
Participants
Input
Output
Participant Of
hasEvent
Inferred From
p-Bmal1:p-Clock,Npas2 binds Ppara gene (Mus musculus)
Authored
May, B  (2015-01-15)
Reviewed
Albrecht, U  (2010-06-23)
D'Eustachio, P  (2009-05-27)
Delaunay, F  (2010-06-23)
Hirota, T  (2010-06-23)
Kay, SA  (2010-06-23)
Created
May, B  (2015-01-16)