p-BMAL1:p-CLOCK,NPAS2 binds SERPINE1 gene

Stable Identifier
R-HSA-5663124
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The phosphorylated BMAL1:CLOCK (ARNTL) heterodimer binds an E-box in the promoter of the PAI-1 gene and activate transcription of PAI-1. NPAS2 is predicted to act redundantly with CLOCK.

Literature References
PubMed ID Title Journal Year
12406875 The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1

van der Bom, JG, Bots, ML, Haverkate, F, Kluft, C, Grobbee, DE

Blood 2003
16857194 Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference

Chong, NW, Codd, V, Chan, D, Samani, NJ

FEBS Lett 2006
12738229 Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2

Schoenhard, JA, Smith, LH, Painter, CA, Eren, M, Johnson, CH, Vaughan, DE

J Mol Cell Cardiol 2003
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