p-BMAL1:p-CLOCK,NPAS2 binds SERPINE1 gene

Stable Identifier
R-HSA-5663124
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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p-BMAL1:p-CLOCK,NPAS2 binds SERPINE1 gene
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The phosphorylated BMAL1:CLOCK (ARNTL) heterodimer binds an E-box in the promoter of the PAI-1 gene and activate transcription of PAI-1. NPAS2 is predicted to act redundantly with CLOCK.

Literature References
PubMed ID Title Journal Year
16857194 Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference

Samani, NJ, Chong, NW, Codd, V, Chan, D

FEBS Lett 2006
12406875 The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1

van der Bom, JG, Bots, ML, Kluft, C, Haverkate, F, Grobbee, DE

Blood 2003
12738229 Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2

Eren, M, Smith, LH, Vaughan, DE, Johnson, CH, Painter, CA, Schoenhard, JA

J Mol Cell Cardiol 2003
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Authored
May, B  (2015-01-15)
Reviewed
Delaunay, F  (2010-06-23)
Kay, SA  (2010-06-23)
Hirota, T  (2010-06-23)
D'Eustachio, P  (2009-05-27)
Albrecht, U  (2010-06-23)
Created
May, B  (2015-01-16)
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