The phosphorylated BMAL1:CLOCK (ARNTL) heterodimer binds an E-box in the promoter of the PAI-1 gene and activate transcription of PAI-1. NPAS2 is predicted to act redundantly with CLOCK.
van der Bom, JG, Bots, ML, Haverkate, F, Kluft, C, Grobbee, DE
Chong, NW, Codd, V, Chan, D, Samani, NJ
Schoenhard, JA, Smith, LH, Painter, CA, Eren, M, Johnson, CH, Vaughan, DE
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