p-BMAL1:p-CLOCK,NPAS2 binds CCRN4L (NOCTURNIN) gene

Stable Identifier
R-HSA-5663138
Type
Reaction [binding]
Species
Homo sapiens
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The phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds an E-box element in the promoter of the NOCTURNIN gene and activates transcription of NOCTURNIN. NPAS2 is predicted to act redundantly with CLOCK.

Literature References
PubMed ID Title Journal Year
18587630 CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter

Li, R, Yue, J, Zhang, Y, Zhou, L, Hao, W, Yuan, J, Qiang, B, Ding, JM, Peng, X, Cao, JM

Mol Cell Biochem 2008
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