p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the PER3 gene

Stable Identifier
R-HSA-9909400
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the PER3 gene
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A dimer of phosphorylated BMAL1:CLOCK heterodimers binds adjacent E-boxes in the PER3 promoter (Matsumura and Akashi 2017, and inferred from mouse homologs). Phosphorylated BMAL1:CLOCK also binds one additional site in the promoter (Matsumura and Akashi 2017). Phosphorylated BMAL1:CLOCK recruits the histone acetyltransferase CREBBP (CBP) and the histone methyltransferase KMT2A (MLL1) (inferred from mouse homologs), and activates transcription.
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p-S97-Bmal1:p-T451,T461-Clock and coactivators bind the Per3 gene (Mus musculus)
Authored
May, B  (2024-05-11)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-05-13)
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