p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene

Stable Identifier
R-HSA-9923010
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene
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Phosphorylated BMAL1:CLOCK heterodimers bind multiple E-boxes in the promoter of the NR1D1 (REV-ERBA) gene (inferred from mouse homologs, also inferred from rat homologs in Triqueneaux et al. 2004). The BMAL1:CLOCK heterodimers recruit the histone methyltransferase KMT2A and the histone acetyltransferase CREBBP (inferred from mouse homologs).
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Inferred From
p-S97-Bmal1:p-T451,T461-Clock and coactivators bind the Nr1d1 (Rev-erba) gene (Mus musculus)
Authored
May, B  (2024-09-21)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-09-29)
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