Reactome | Spsb2 [cytosol]

Spsb2 [cytosol]

Stable Identifier

R-RNO-976048

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

SPSB2, Q5M877

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Spsb2 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Spsb2 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Spsb2 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Spsb2 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Spsb2 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Spsb2 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Spsb2 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Spsb2 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Spsb2 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Spsb2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q5M877

Gene Names

Spsb2

Reference Genes

BioGPS Gene:297592 Spsb2

ENSEMBL:ENSRNOG00000015125

ENSEMBL:ENSRNOG00000047113

ENSEMBL:ENSRNOG00055010547

ENSEMBL:ENSRNOG00060032523

ENSEMBL:ENSRNOG00065029467

KEGG:rno:297592 Spsb2

Monarch:297592 Spsb2

NCBI Gene:297592 Spsb2

UCSC:Q5M877 Spsb2

Other Identifiers

10858702

1373742_at

17601673

17601675

17601677

17601679

17601681

17601683

17601685

17601687

17601689

17601691

17601693

17601695

17601697

17601699

17601701

17601707

17601709

17601711

17601713

17601715

17601717

17601719

17601721

17601723

17601725

17601727

17601729

17601731

17601733

17601735

17601737

17601739

17601741

17601743

17601745

17601747

17601749

17601751

17601753

17601755

17601757

17601759

17601761

17601763

17601765

17601767

17601769

17601771

17601773

17601775

17601777

17601779

17601781

17601783

17601785

17601787

17601789

17601791

17601793

17601795

17601797

17601799

17601801

17601803

17601805

17601807

17601809

17601811

17601813

17601815

17601817

17601819

17601821

17787125

297592

5625805

5748702

5871599

5897547

6125485

6175462

6591123

6661158

GE1131878

GO:0005515

GO:0005829

GO:0006511

GO:0016567

GO:0035556

GO:0060090

GO:1990756

ILMN_1360179

PH_rn_0004708

rc_AI113003_at

Participates

as a member of

CUL5-box protein [cytosol] (Rattus norvegicus)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)

Inferred From

SPSB2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001381285.1, NP_001381286.1, NP_001009660.1

ENSEMBL

ENSRNOT00000020493, ENSRNOP00000020493, ENSRNOG00000015125

PRO

Q5M877

RGD

1310854

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