Reactome | SPSB2 [cytosol]

SPSB2 [cytosol]

Stable Identifier

R-CFA-976048

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

SPSB2, A0A8I3PR64

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Neddylation (Canis familiaris)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Canis familiaris)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB2 [cytosol] (Canis familiaris)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB2 [cytosol] (Canis familiaris)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB2 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB2 [cytosol] (Canis familiaris)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB2 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB2 [cytosol] (Canis familiaris)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB2 [cytosol] (Canis familiaris)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PR64

Gene Names

SPSB2

Reference Genes

BioGPS Gene:477710 SPSB2

ENSEMBL:ENSCAFG00845026990.1

KEGG:cfa:477710 SPSB2

Monarch:477710 SPSB2

NCBI Gene:477710 SPSB2

UCSC:A0A8I3PR64 SPSB2

Other Identifiers

477710

Cfa.6937.1.A1_at

CfaAffx.22419.1.S1_at

CfaAffx.22419.1.S1_s_at

GO:0005515

GO:0005737

GO:0005829

GO:0006511

GO:0016567

GO:0019005

GO:0030163

GO:0035556

GO:0043161

GO:0060090

GO:1990756

Participates

as a member of

CUL5-box protein [cytosol] (Canis familiaris)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)

Inferred From

SPSB2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005637269.1, XP_038432577.1, XP_038295079.1, XP_005637271.1, XP_005637270.1, XP_022266669.1, XP_038432579.1, XP_038432578.1, XP_038432580.1, XP_038295080.1, XP_038295082.1, XP_038295081.1, XP_038295083.1

ENSEMBL

ENSCAFG00845026990, ENSCAFT00845047535, ENSCAFP00845037298