Reactome | CHRND [plasma membrane]

CHRND [plasma membrane]

Stable Identifier

R-HSA-507847

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Acetylcholine receptor subunit delta, ACHD_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly sodium permeable postsynaptic acetylcholine nicotinic receptors (Homo sapiens)
        
        Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRND [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRND [plasma membrane] (Homo sapiens)
        
        O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRND [plasma membrane] (Homo sapiens)
      - Presynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly sodium permeable postsynaptic acetylcholine nicotinic receptors (Homo sapiens)
        
        Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRND [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRND [plasma membrane] (Homo sapiens)
        
        O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRND [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07001 CHRND

Gene Names

CHRND, ACHRD

Chain

signal peptide:1-21, chain:22-517

Reference Genes

BioGPS Gene:1144 CHRND

COSMIC (genes):CHRND CHRND

CTD Gene:1144 CHRND

dbSNP Gene:1144 CHRND

ENSEMBL:ENSG00000135902 CHRND

ENSEMBL_homo_sapiens_GENE:ENSG00000135902.10 CHRND

HGNC:1965 CHRND

KEGG Gene (Homo sapiens):1144 CHRND

Monarch:1144 CHRND

NCBI Gene:1144 CHRND

OMIM:100720 CHRND

UCSC:Q07001 CHRND

Reference Transcript

Other Identifiers

1144

11746266_a_at

11746267_x_at

11750952_a_at

11750953_x_at

11751407_a_at

11760340_at

16892288

207024_PM_at

207024_at

2532380

2532381

2532382

2532383

2532385

2532386

2532389

2532390

2532391

2532392

2532393

2532394

2532396

2532397

2532398

31554_at

8049152

A_23_P430558

GE59803

GO:0003009

GO:0003012

GO:0004888

GO:0005215

GO:0005216

GO:0005230

GO:0005886

GO:0005892

GO:0006811

GO:0006812

GO:0006936

GO:0007154

GO:0007165

GO:0015276

GO:0016020

GO:0022848

GO:0023052

GO:0031594

GO:0034220

GO:0042166

GO:0042391

GO:0043005

GO:0043226

GO:0045202

GO:0045211

GO:0048630

GO:0048856

GO:0050877

GO:0050881

GO:0050905

GO:0055085

GO:0060078

GO:0060079

GO:0060089

GO:0095500

GO:0099634

GO:1904315

HMNXSV003009058

HMNXSV003032414

ILMN_1661355

PH_hs_0022707

TC02001402.hg

X55019_s_at

g4557460_3p_at

Participates

as a member of

Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)

Inferred To

acr-12 [plasma membrane] (Caenorhabditis elegans)

unc-63 [plasma membrane] (Caenorhabditis elegans)

acr-8 [plasma membrane] (Caenorhabditis elegans)

lev-1 [plasma membrane] (Caenorhabditis elegans)

Homologues of CHRND [plasma membrane] (Caenorhabditis elegans)

Homologues of CHRND [plasma membrane] (Drosophila melanogaster)

nAChRalpha2 [plasma membrane] (Drosophila melanogaster)

nAChRalpha3 [plasma membrane] (Drosophila melanogaster)

unc-29 [plasma membrane] (Caenorhabditis elegans)

chrnd [plasma membrane] (Xenopus tropicalis)

acr-3 [plasma membrane] (Caenorhabditis elegans)

nAChRalpha4 [plasma membrane] (Drosophila melanogaster)

acr-6 [plasma membrane] (Caenorhabditis elegans)

nAChRbeta2 [plasma membrane] (Drosophila melanogaster)

acr-2 [plasma membrane] (Caenorhabditis elegans)

lev-8 [plasma membrane] (Caenorhabditis elegans)

Chrnd [plasma membrane] (Mus musculus)

Chrnd [plasma membrane] (Rattus norvegicus)

CHRND [plasma membrane] (Bos taurus)

CHRND [plasma membrane] (Canis familiaris)

CHRND [plasma membrane] (Gallus gallus)

nAChRalpha1 [plasma membrane] (Drosophila melanogaster)

nAChRbeta1 [plasma membrane] (Drosophila melanogaster)

unc-38 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001298125.1, NP_001298124.1, NP_000742.1, NP_001243586.1

Guide to Pharmacology - Targets

476

OpenTargets

ENSG00000135902

GeneCards

Q07001

HPA

ENSG00000135902-CHRND

ZINC - Substances

ACHD_HUMAN

ZINC target

Q07001

Ensembl

ENSP00000438380, ENST00000543200, ENSG00000135902, ENST00000258385, ENSP00000258385

PRO

Q07001

Pharos - Targets

Q07001

Orphanet

15450

ZINC - Predictions - Purchasable

ACHD_HUMAN

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99758 ABCA3	11	ABCA3 T1173R [lamellar body membrane] (R-HSA-5683705) ABCA3 W1142* [lamellar body membrane] (R-HSA-5683691) ABCA3 [lamellar body membrane] (R-HSA-1369005) ABCA3 T1114M [lamellar body membrane] (R-HSA-5688390) ABCA3 N568D [lamellar body membrane] (R-HSA-5688388) ABCA3 E690K [lamellar body membrane] (R-HSA-5688389) ABCA3 E292V [lamellar body membrane] (R-HSA-5688394) ABCA3 L1553P [lamellar body membrane] (R-HSA-5683671) ABCA3 L326P [lamellar body membrane] (R-HSA-5683666) ABCA3 D253H [lamellar body membrane] (R-HSA-5683697) ABCA3 L101P [lamellar body membrane] (R-HSA-5683658)	0.527	2
UniProt:Q5K4L6 SLC27A3	1	SLC27A3 [mitochondrial matrix] (R-HSA-5216184)	0.527	2
UniProt:Q14534 SQLE	1	SQLE [endoplasmic reticulum membrane] (R-HSA-191395)	0.527	2
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.527	2
UniProt:Q9NZJ5 EIF2AK3	3	EIF2AK3 [endoplasmic reticulum membrane] (R-HSA-381046) EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713456) EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713454)	0.527	2
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.527	2