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HLA class I histocompatibility antigen, E alpha chain precursor [early endosome membrane]
Stable Identifier
R-HSA-1236744
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome membrane
Synonyms
HLAE_HUMAN, HLA-E
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
Endosomal/Vacuolar pathway (Homo sapiens)
Loading of antigen peptide onto MHC class I molecule (Homo sapiens)
Antigen peptide bound class I MHC [early endosome membrane] (Homo sapiens)
Class I MHC:B2M [early endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
HLA class I histocompatibility antigen, E alpha chain precursor [early endosome membrane] (Homo sapiens)
Class I MHC:B2M [early endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
HLA class I histocompatibility antigen, E alpha chain precursor [early endosome membrane] (Homo sapiens)
Translocation of peptide bound MHC class I complex to cell surface (Homo sapiens)
Antigen peptide bound class I MHC [early endosome membrane] (Homo sapiens)
Class I MHC:B2M [early endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
HLA class I histocompatibility antigen, E alpha chain precursor [early endosome membrane] (Homo sapiens)
Trimming of peptides by IRAP in endocytic vesicles (Homo sapiens)
IRAP in complex with MHC class I [early endosome membrane] (Homo sapiens)
Class I MHC:B2M [early endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
HLA class I histocompatibility antigen, E alpha chain precursor [early endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13747 HLA-E
Gene Names
HLA-E, HLA-6.2, HLAE
Chain
signal peptide:1-21, chain:22-358, chain:22-
Reference Genes
BioGPS Gene:3133 HLA-E
COSMIC (genes):HLA-E HLA-E
CTD Gene:3133 HLA-E
dbSNP Gene:3133 HLA-E
ENSEMBL:ENSG00000204592 HLA-E
HGNC:4962 HLA-E
KEGG:hsa:3133 HLA-E
Monarch:3133 HLA-E
NCBI Gene:3133 HLA-E
OMIM:143010 HLA-E
UCSC:P13747 HLA-E
Reference Transcript
RefSeq:NM_005516.5 HLA-E
Other Identifiers
11723195_x_at
11744829_s_at
11748332_x_at
11751618_x_at
11753404_x_at
11758879_s_at
17006261
17027443
17030288
17032993
17035115
17037774
17040488
200904_PM_at
200904_at
200905_PM_x_at
200905_x_at
217456_3p_x_at
217456_PM_x_at
217456_x_at
2900990
2901162
2901216
2901621
2901622
2901623
2901624
2901625
2901626
2901627
2901628
2901629
2901630
2901631
2901632
2901633
2901634
2901635
2901636
2901637
2901638
2901639
2901641
2901642
2901643
2901644
2901645
2901646
2901647
2901648
2948945
2948946
3133
32321_at
8117890
8177788
8179103
A_14_P102409
A_23_P30848
A_24_P326082
A_32_P460973
GE61370
GE81522
GO:0000139
GO:0001815
GO:0001916
GO:0002250
GO:0002376
GO:0002474
GO:0002476
GO:0002477
GO:0002486
GO:0002519
GO:0002639
GO:0002715
GO:0002717
GO:0002729
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0005794
GO:0005886
GO:0006955
GO:0009897
GO:0009986
GO:0012507
GO:0016020
GO:0019731
GO:0019882
GO:0030670
GO:0030881
GO:0031901
GO:0032398
GO:0032736
GO:0032753
GO:0032759
GO:0032760
GO:0032815
GO:0032816
GO:0032819
GO:0036037
GO:0042130
GO:0042270
GO:0042288
GO:0042605
GO:0042608
GO:0042612
GO:0043226
GO:0045087
GO:0045953
GO:0045954
GO:0046703
GO:0050830
GO:0055038
GO:0070062
GO:0098542
GO:0098553
GO:2000566
GO:2001187
HMNXSV003053079
Hs.181392.0.A2_3p_at
Hs.181392.1.A1_3p_a_at
Hs.181392.1.A1_3p_x_at
ILMN_1765258
PH_hs_0038975
TC06000338.hg
TC6_cox_hap2000036.hg
TC6_dbb_hap3000029.hg
TC6_mann_hap4000031.hg
TC6_mcf_hap5000023.hg
TC6_qbl_hap6000029.hg
TC6_ssto_hap7000029.hg
X56841_at
Participates
as a member of
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
Other forms of this molecule
HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane]
HLA class I histocompatibility antigen, E alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
HLA class I histocompatibility antigen, E alpha chain precursor [Golgi membrane]
HLA class I histocompatibility antigen, E alpha chain precursor [ER to Golgi transport vesicle membrane]
HLA class I histocompatibility antigen, E alpha chain precursor [recycling endosome membrane]
HLA class I histocompatibility antigen, E alpha chain precursor [phagocytic vesicle membrane]
Inferred To
mhc1zba [early endosome membrane]
(Danio rerio)
mhc1zca [early endosome membrane]
(Danio rerio)
mhc1zda [early endosome membrane]
(Danio rerio)
mhc1laa [early endosome membrane]
(Danio rerio)
HLA class I histocompatibility antigen, E alpha chain precursor [early endosome membrane]
(Gallus gallus)
Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [early endosome membrane]
(Danio rerio)
Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [early endosome membrane]
(Gallus gallus)
mhc1zea [early endosome membrane]
(Danio rerio)
mhc1zfa [early endosome membrane]
(Danio rerio)
mhc1uma [early endosome membrane]
(Danio rerio)
BFIV21 [early endosome membrane]
(Gallus gallus)
BF1 [early endosome membrane]
(Gallus gallus)
mhc1uba [early endosome membrane]
(Danio rerio)
Cross References
RefSeq
NP_005507.3
OpenTargets
ENSG00000204592
ENSEMBL
ENST00000415649
,
ENSP00000400458
,
ENSP00000402694
,
ENSP00000409910
,
ENST00000427936
,
ENST00000425603
,
ENSP00000397420
,
ENST00000383597
,
ENST00000444683
,
ENSP00000390707
,
ENSP00000365817
,
ENST00000415289
,
ENST00000376630
,
ENSP00000373091
HPA
ENSG00000204592-HLA-E
PRO
P13747
Pharos - Targets
P13747
GlyGen
P13747
PDB
8QFY
,
2ESV
,
1KTL
,
7BH8
,
6ZKY
,
6ZKZ
,
3BZE
,
3BZF
,
6GHN
,
6GH1
,
3AM8
,
3CDG
,
6GGM
,
6GH4
,
6GL1
,
7NDT
,
5W1W
,
1MHE
,
7NDU
,
7NDQ
,
1KPR
,
7P4B
,
7P49
,
3CII
,
5W1V
,
6ZKW
,
6ZKX
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q09328 MGAT5
1
MGAT5 [Golgi membrane]
(R-HSA-975896)
0.527
2
UniProt:Q9NZJ5 EIF2AK3
3
EIF2AK3 [endoplasmic reticulum membrane]
(R-HSA-381046)
EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713456)
EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713454)
0.527
2
UniProt:Q96JA1 LRIG1
2
Ub-LRIG1 [plasma membrane]
(R-HSA-8875434)
LRIG1 [plasma membrane]
(R-HSA-197745)
0.527
2
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