LBR binds KPNB1

Stable Identifier
R-HSA-9624798
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation of LBR (lamin B receptor) at serine residue S71 drives binding of LBR to KPNB1 (importin beta) (Lu et al. 2010). This prevents premature association of nascent nuclear membranes with chromatin in anaphase (Tseng and Chen 2011). Dephosphorylation of this site is suggested to promote NE reassembly (Tseng and Chen 2011).

Literature References
PubMed ID Title Journal Year
20576617 Requirement for lamin B receptor and its regulation by importin {beta} and phosphorylation in nuclear envelope assembly during mitotic exit

Lu, X, Shi, Y, Lu, Q, Ma, Y, Luo, J, Wang, Q, Ji, J, Jiang, Q, Zhang, C

J. Biol. Chem. 2010
Participants
Participant Of
Orthologous Events
Authored
Created