LBR binds KPNB1

Stable Identifier
R-HSA-9624798
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nuclear envelope, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
LBR binds KPNB1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation of LBR (lamin B receptor) at serine residue S71 drives binding of LBR to KPNB1 (importin beta) (Lu et al. 2010). This prevents premature association of nascent nuclear membranes with chromatin in anaphase (Tseng and Chen 2011). Dephosphorylation of this site is suggested to promote NE reassembly (Tseng and Chen 2011).

Literature References
PubMed ID Title Journal Year
20576617 Requirement for lamin B receptor and its regulation by importin {beta} and phosphorylation in nuclear envelope assembly during mitotic exit

Lu, X, Shi, Y, Lu, Q, Ma, Y, Luo, J, Wang, Q, Ji, J, Jiang, Q, Zhang, C

J. Biol. Chem. 2010
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
LBR binds KPNB1 (Bos taurus)
LBR binds KPNB1 (Canis familiaris)
LBR binds KPNB1 (Danio rerio)
LBR binds KPNB1 (Gallus gallus)
LBR binds KPNB1 (Mus musculus)
LBR binds KPNB1 (Saccharomyces cerevisiae)
LBR binds KPNB1 (Schizosaccharomyces pombe)
LBR binds KPNB1 (Sus scrofa)
LBR binds KPNB1 (Xenopus tropicalis)
Authored
Gerace, L  (2019-11-07)
Created
Orlic-Milacic, M  (2018-10-15)