LBR binds KPNB1

Stable Identifier
R-HSA-9624798
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nuclear envelope, cytosol
ReviewStatus
5/5
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LBR binds KPNB1
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Phosphorylation of LBR (lamin B receptor) at serine residue S71 drives binding of LBR to KPNB1 (importin beta) (Lu et al. 2010). This prevents premature association of nascent nuclear membranes with chromatin in anaphase (Tseng and Chen 2011). Dephosphorylation of this site is suggested to promote NE reassembly (Tseng and Chen 2011).
Literature References
PubMed ID Title Journal Year
20576617 Requirement for lamin B receptor and its regulation by importin {beta} and phosphorylation in nuclear envelope assembly during mitotic exit

Lu, X, Ji, J, Lu, Q, Shi, Y, Jiang, Q, Ma, Y, Zhang, C, Wang, Q, Luo, J

J. Biol. Chem. 2010
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Authored
Gerace, L  (2019-11-07)
Created
Orlic-Milacic, M  (2018-10-15)
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