Reactome | PXLP-K396-GAD2 [plasma membrane]

PXLP-K396-GAD2 [plasma membrane]

Stable Identifier

R-HSA-936509

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Glutamate decarboxylase 2, DCE2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q05329 GAD2

Gene Names

GAD2, GAD65

Chain

chain:1-585

Reference Genes

BioGPS Gene:2572 GAD2

COSMIC (genes):GAD2 GAD2

CTD Gene:2572 GAD2

dbSNP Gene:2572 GAD2

ENSEMBL:ENSG00000136750 GAD2

ENSEMBL_homo_sapiens_GENE:ENSG00000136750.13 GAD2

HGNC:4093 GAD2

KEGG Gene (Homo sapiens):2572 GAD2

Monarch:2572 GAD2

NCBI Gene:2572 GAD2

OMIM:138275 GAD2

Reference Transcript

Other Identifiers

11730977_a_at

11730978_a_at

11737613_a_at

16703382

206780_PM_at

206780_at

211264_PM_at

211264_at

216651_PM_s_at

216651_s_at

2572

32279_at

32280_at

3239678

3239679

3239680

3239681

3239682

3239684

3239686

3239687

3239690

3239692

3239693

3239695

3239701

3239712

3239713

3239714

3239721

3239722

3239723

3239725

3239726

3239727

3239728

3239729

3239730

3239731

3239732

3239733

3239734

3239736

7926766

A_14_P107931

A_23_P75008

A_33_P3420530

GE58074

GO:0000139

GO:0003824

GO:0004351

GO:0005515

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006520

GO:0006540

GO:0007268

GO:0009410

GO:0009449

GO:0016020

GO:0016595

GO:0016829

GO:0016830

GO:0016831

GO:0019752

GO:0023052

GO:0030170

GO:0030424

GO:0030672

GO:0031410

GO:0031982

GO:0042220

GO:0042734

GO:0042995

GO:0043226

GO:0044877

GO:0045202

GO:0048471

GO:0060077

GO:0061202

GO:0098793

GO:0098982

HMNXSV003017356

Hs.170808.2.S1_3p_a_at

Hs2.170808.3.S1_3p_s_at

ILMN_1728301

M74826_at

M81882_at

PH_hs_0023154

TC10000180.hg

g182933_3p_at

g4503874_3p_at

Participates

as a component of

Other forms of this molecule

PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

Inferred To

Homologues of PXLP-K396-GAD2 [plasma membrane] (Sus scrofa)

PXLP-K396-GAD2 [plasma membrane] (Canis familiaris)

PXLP-K396-GAD2 [plasma membrane] (Drosophila melanogaster)

PXLP-K396-GAD2 [plasma membrane] (Mus musculus)

PXLP-K396-GAD2 [plasma membrane] (Rattus norvegicus)

PXLP-K396-GAD2 [plasma membrane] (Sus scrofa)

unc-25 [plasma membrane] (Caenorhabditis elegans)

GAD2 [plasma membrane] (Bos taurus)

GAD2 [plasma membrane] (Sus scrofa)

Modified Residues

Name

N6-pyridoxal phosphate-L-lysine at 396

Coordinate

396

PsiMod Name

N6-pyridoxal phosphate-L-lysine [MOD:00128]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.

Cross References

RefSeq

NP_001127838.1, NP_000809.1

Guide to Pharmacology - Targets

1273

OpenTargets

ENSG00000136750

IntEnz

4.1.1.15

HPA

ENSG00000136750-GAD2

GeneCards

Q05329

Ensembl

ENST00000259271, ENST00000376261, ENSG00000136750, ENSP00000365437, ENSP00000259271

PRO

Q05329

Pharos - Targets

Q05329

Orphanet

27039

HMDB Protein

HMDBP00702

PDB

2OKK, 1ES0

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96B96 LDAF1			0.718	6
UniProt:Q969L2 MAL2			0.718	6
UniProt:Q15041 AR6P1			0.718	6
UniProt:A8MV81 HIGD1C	1	HIGD1C [mitochondrial inner membrane] (R-HSA-9865734)	0.556	3
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511) AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262)	0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:A0PK00 T120B			0.556	3
UniProt:Q8WZ55 BSND	1	BSND [plasma membrane] (R-HSA-2854996)	0.556	3
UniProt:Q6PIF2 SYCE2	1	SYCE2 [nucleoplasm] (R-HSA-912451)	0.556	3
UniProt:Q96GL9 F163A			0.556	3
UniProt:Q8N9I5 FADS6			0.556	3
UniProt:Q06432 CCG1			0.556	3
UniProt:Q96Q80 DERL3	1	DERL3 [endoplasmic reticulum membrane] (R-HSA-8866516)	0.556	3
UniProt:Q9NRY5 FAM114A2	2	FAM114A2(1-327)-BRAF(439-766) fusion [cytosol] (R-HSA-6802321) FAM114A2(1-327)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802525)	0.556	3
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560)	0.556	3
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:Q5EB52 MEST			0.556	3
UniProt:Q9BUN8 DERL1	1	DERL1 [endoplasmic reticulum membrane] (R-HSA-6781898)	0.556	3
UniProt:Q9UBN6 TNFRSF10D	1	TNFRSF10D [plasma membrane] (R-HSA-5633374)	0.556	3
UniProt:Q8IZV5 RDH10	1	RDH10 [endoplasmic reticulum membrane] (R-HSA-2454090)	0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:Q9H400 LIME1			0.556	3
UniProt:Q8N3Y7 SDR16C5	1	RDHE2 [endoplasmic reticulum membrane] (R-HSA-5621649)	0.556	3
UniProt:Q8WTS1 ABHD5	2	ABHD5 [lipid droplet] (R-HSA-163485) ABHD5 [cytosol] (R-HSA-163531)	0.556	3
UniProt:Q86UF1 TSPAN33	2	TSPAN33 [plasma membrane] (R-HSA-9010024) TSPAN33 [endoplasmic reticulum lumen] (R-HSA-9010054)	0.556	3
UniProt:Q5T9G4-2 ARMC12			0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:O60906 SMPD2	1	SMPD2 [plasma membrane] (R-HSA-194337)	0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q6ZWK4 RHEX			0.556	3
UniProt:Q8N8Q1 C56D1			0.556	3
UniProt:O43761 SNG3			0.556	3
UniProt:Q9HC36 MRM3	1	RNMTL1 [mitochondrial matrix] (R-HSA-6793067)	0.556	3
UniProt:Q6E0U4 DMKN	1	DMKN [secretory granule lumen] (R-HSA-9839542)	0.556	3
UniProt:P55056 APOC4	1	APOC4 [extracellular region] (R-HSA-5215930)	0.556	3
UniProt:O60664 PLIN3	7	p-PLIN3 [lysosomal lumen] (R-HSA-9639396) p-PLIN3 [cytosol] (R-HSA-9613664) p-PLIN3 [lipid droplet] (R-HSA-9613539) PLIN3 [lipid droplet] (R-HSA-9613337) p-PLIN3 [late endosome lumen] (R-HSA-9639393) PLIN3 [cytosol] (R-HSA-6814628) PLIN3 [transport vesicle] (R-HSA-6813900)	0.556	3
UniProt:Q5BJH2-2 TMEM128			0.556	3
UniProt:Q96DZ9 CKLF5			0.556	3
UniProt:Q96AL5 Q96AL5			0.556	3

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