Reactome | p-PLIN3 [late endosome lumen]

p-PLIN3 [late endosome lumen]

Stable Identifier

R-HSA-9639393

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

late endosome lumen

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Locations in the PathwayBrowser

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Autophagy (Homo sapiens)

- Late endosomal microautophagy (Homo sapiens)
  - Substrate translocates into late endosomal lumen (Homo sapiens)
    - PL:HSPA8:Autophagy substrate [late endosome lumen] (Homo sapiens)
      - HSPA8 bound autophagic substrates [late endosome lumen] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [late endosome lumen] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [late endosome lumen] (Homo sapiens)
        
        p-PLIN3 [late endosome lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60664 PLIN3

Gene Names

PLIN3, M6PRBP1, TIP47

Chain

initiator methionine:, chain:2-434

Reference Genes

BioGPS Gene:10226 PLIN3

COSMIC (genes):PLIN3 PLIN3

CTD Gene:10226 PLIN3

dbSNP Gene:10226 PLIN3

ENSEMBL:ENSG00000105355 PLIN3

ENSEMBL_homo_sapiens_GENE:ENSG00000105355.9 PLIN3

HGNC:16893 PLIN3

KEGG Gene (Homo sapiens):10226 PLIN3

Monarch:10226 PLIN3

NCBI Gene:10226 PLIN3

OMIM:602702 PLIN3

UCSC:O60664 PLIN3

Reference Transcript

Other Identifiers

10226

11722993_x_at

16867414

202122_3p_s_at

202122_PM_s_at

202122_s_at

3847006

3847007

3847008

3847009

3847010

3847011

3847013

3847014

3847015

3847016

3847017

3847019

3847020

3847021

3847022

40169_at

51002_s_at

61324_at

8032909

A_23_P101707

GE54537

GO:0005515

GO:0005737

GO:0005768

GO:0005794

GO:0005811

GO:0005829

GO:0010008

GO:0010890

GO:0016020

GO:0016192

GO:0019915

GO:0030133

GO:0031410

GO:0042149

GO:0043226

GO:0045296

GO:1905691

HMNXSV003038850

ILMN_1660021

PH_hs_0031785

TC19001072.hg

g5032182_3p_x_at

Participates

as a member of

Phosphorylated PLINs from lipid droplet surface [late endosome lumen] (Homo sapiens)

Other forms of this molecule

p-PLIN3 [lysosomal lumen]

p-PLIN3 [cytosol]

p-PLIN3 [lipid droplet]

PLIN3 [lipid droplet]

PLIN3 [cytosol]

PLIN3 [transport vesicle]

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_005808.3, NP_001157661.1, NP_001157666.1

OpenTargets

ENSG00000105355

HPA

ENSG00000105355-PLIN3

GeneCards

O60664

Ensembl

ENST00000592528, ENST00000221957, ENSP00000467803, ENSG00000105355, ENSP00000465596, ENSP00000221957, ENST00000585479

PRO

O60664

Pharos - Targets

O60664

HMDB Protein

HMDBP01751

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9WMX2-PRO_0000037551			0.602	5
UniProt:Q13596 SNX1			0.601	4
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:Q9NQG6 MID51			0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:O95562 SFT2B			0.556	3
UniProt:Q9C0E8-2 LNPK			0.556	3
UniProt:Q9HB07 MYG1			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:Q9BQA9 CYBC1			0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:O43759-2 SYNGR1			0.556	3
UniProt:O60749 SNX2	2	SNX2 [Golgi membrane] (R-HSA-434333) SNX2 [cytoplasmic vesicle membrane] (R-HSA-434216)	0.556	3
UniProt:Q9P0S9 TM14C			0.556	3
UniProt:Q8WTS1 ABHD5	2	ABHD5 [lipid droplet] (R-HSA-163485) ABHD5 [cytosol] (R-HSA-163531)	0.556	3
UniProt:Q96AL5 Q96AL5			0.556	3
UniProt:Q96DZ9 CKLF5			0.556	3
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.556	3
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.556	3
UniProt:O43761 SNG3			0.556	3
UniProt:Q9NVG8 TBC1D13	1	TBC1D13 [cytosol] (R-HSA-8854148)	0.556	3
UniProt:Q9H444 CHMP4B	2	CHMP4B [cytosol] (R-HSA-917708) CHMP4B [endosome membrane] (R-HSA-9631202)	0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:Q8TB40 ABHD4	1	ABHD4 [endoplasmic reticulum membrane] (R-HSA-5694582)	0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:Q9Y6X2 PIAS3	1	PIAS3 [nucleoplasm] (R-HSA-2993764)	0.556	3
UniProt:Q05329 GAD2	2	PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888582) PXLP-K396-GAD2 [plasma membrane] (R-HSA-936509)	0.556	3
UniProt:Q9BW92 TARS2	1	TARS2(1-?) [mitochondrial matrix] (R-HSA-379590)	0.556	3

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