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SEC22A [ER to Golgi transport vesicle membrane]
Stable Identifier
R-HSA-5688560
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ER to Golgi transport vesicle membrane
Synonyms
Vesicle-trafficking protein SEC22a, SC22A_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96IW7 SEC22A
Gene Names
SEC22A, SEC22L2
Chain
initiator methionine:1, chain:2-307
Reference Genes
BioGPS Gene:26984 SEC22A
COSMIC (genes):SEC22A SEC22A
CTD Gene:26984 SEC22A
dbSNP Gene:26984 SEC22A
ENSEMBL:ENSG00000121542 SEC22A
HGNC:20260 SEC22A
KEGG:hsa:26984 SEC22A
Monarch:26984 SEC22A
NCBI Gene:26984 SEC22A
OMIM:612442 SEC22A
UCSC:Q96IW7 SEC22A
Reference Transcript
RefSeq:XM_054346151.1 SEC22A
RefSeq:NM_012430.4 SEC22A
RefSeq:XM_054346153.1 SEC22A
RefSeq:XM_054346149.1 SEC22A
RefSeq:XM_054346152.1 SEC22A
RefSeq:XM_011512673.4 SEC22A
RefSeq:XM_047447957.1 SEC22A
RefSeq:XM_011512675.4 SEC22A
RefSeq:XM_011512676.4 SEC22A
RefSeq:XM_047447958.1 SEC22A
RefSeq:XM_054346150.1 SEC22A
Other Identifiers
11720987_at
11720988_at
16944763
218703_PM_at
218703_at
238078_PM_at
238078_at
2639308
2639310
2639311
2639312
2639313
2639314
2639316
2639317
2639318
2639325
2639326
2639327
2639328
2639329
2639330
2639340
2639341
2639342
2639348
2639352
2639353
2639354
2639355
2639356
2639357
2639358
2639359
2639360
2639362
2639364
2639366
2639368
26984
46901_at
48596_at
8082153
A_14_P117180
A_23_P259874
A_32_P233019
GE79743
GO:0005484
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0006888
GO:0006890
GO:0012505
GO:0015031
GO:0016020
GO:0016192
GO:0042470
GO:0060090
GO:0061024
GO:0061025
HMNXSV003014068
Hs.53126.0.A1_3p_at
ILMN_1775036
PH_hs_0025151
TC03003364.hg
g6912647_3p_at
Participates
as a candidate of
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
Other forms of this molecule
SEC22A [endoplasmic reticulum membrane]
SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane]
Inferred To
Sec22a [ER to Golgi transport vesicle membrane]
(Mus musculus)
Sec22a [ER to Golgi transport vesicle membrane]
(Rattus norvegicus)
SEC22A [ER to Golgi transport vesicle membrane]
(Bos taurus)
SEC22A [ER to Golgi transport vesicle membrane]
(Canis familiaris)
SEC22A [ER to Golgi transport vesicle membrane]
(Gallus gallus)
SEC22A [ER to Golgi transport vesicle membrane]
(Sus scrofa)
sec22a [ER to Golgi transport vesicle membrane]
(Danio rerio)
sec22a [ER to Golgi transport vesicle membrane]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011510975.1
,
XP_054202127.1
,
XP_054202126.1
,
XP_054202128.1
,
XP_047303914.1
,
NP_036562.2
,
XP_054202124.1
,
XP_011510978.1
,
XP_011510977.1
,
XP_054202125.1
,
XP_047303913.1
ENSEMBL
ENST00000309934
,
ENSP00000417972
,
ENSG00000121542
,
ENSP00000310521
,
ENST00000492595
OpenTargets
ENSG00000121542
HPA
ENSG00000121542-SEC22A
GeneCards
SEC22A
PRO
Q96IW7
Pharos - Targets
Q96IW7
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92838 EDA
1
EDA [plasma membrane]
(R-HSA-5667156)
0.781
7
UniProt:P11686 SFTPC
9
pro-SFTPC P115L [endoplasmic reticulum membrane]
(R-HSA-5688352)
pro-SFTPC P30L [endoplasmic reticulum membrane]
(R-HSA-5688365)
pro-SFTPC [endoplasmic reticulum membrane]
(R-HSA-5683842)
pro-SFTPC [multivesicular body lumen]
(R-HSA-5685298)
SFTPC [extracellular region]
(R-HSA-5683685)
SFTPC [clathrin-coated endocytic vesicle]
(R-HSA-5686342)
SFTPC [lamellar body]
(R-HSA-5683717)
SFTPC(24-58) [multivesicular body lumen]
(R-HSA-5685899)
SFTPC(59-197) [multivesicular body lumen]
(R-HSA-5685871)
0.718
6
UniProt:Q12846 STX4
4
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.718
6
UniProt:Q9UGN4 CD300A
3
CD300A [ficolin-1-rich granule membrane]
(R-HSA-6801282)
CD300A [plasma membrane]
(R-HSA-5696336)
CD300A [tertiary granule membrane]
(R-HSA-6801317)
0.556
3
UniProt:Q8IUN9 CLEC10A
1
CLEC10A [plasma membrane]
(R-HSA-1472863)
0.556
3
UniProt:P32942 ICAM3
1
ICAM3 [plasma membrane]
(R-HSA-197682)
0.556
3
UniProt:Q6PIZ9 TRAT1
1
p-Y63,Y79,Y110-TRAT1 [plasma membrane]
(R-HSA-202201)
0.556
3
UniProt:Q9BRI3 SLC30A2
2
SLC30A2 [endosome membrane]
(R-HSA-435363)
SLC30A2 [synaptic vesicle membrane]
(R-HSA-4084714)
0.556
3
UniProt:O60883 GPR37L1
1
GPR37L1 [plasma membrane]
(R-HSA-5336178)
0.556
3
UniProt:Q96A56 TP53INP1
1
TP53INP1 [nucleoplasm]
(R-HSA-3215226)
0.556
3
UniProt:Q9NR28 DIABLO
2
DIABLO [cytosol]
(R-HSA-114298)
DIABLO [mitochondrial intermembrane space]
(R-HSA-64637)
0.556
3
UniProt:P21217 FUT3
1
FUT3 [Golgi membrane]
(R-HSA-5693934)
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.556
3
UniProt:P17643 TYRP1
1
TYRP1 [melanosome membrane]
(R-HSA-8878574)
0.556
3
UniProt:Q9UP52 TFR2
1
TFR2 [plasma membrane]
(R-HSA-5691118)
0.556
3
UniProt:P50876 RNF144A
1
RNF144A [endosome membrane]
(R-HSA-8938771)
0.556
3
UniProt:Q6P5S7 RNASEK
1
RNASEK [endosome membrane]
(R-HSA-9945859)
0.556
3
UniProt:Q05329 GAD2
2
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888582)
PXLP-K396-GAD2 [plasma membrane]
(R-HSA-936509)
0.556
3
UniProt:P43657 LPAR6
1
LPAR6 [plasma membrane]
(R-HSA-417913)
0.556
3
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.556
3
UniProt:P35232 PHB1
2
PHB [cytosol]
(R-HSA-5672944)
PHB [mitochondrial inner membrane]
(R-HSA-8953720)
0.556
3
UniProt:Q9NX18 SDHAF2
1
SDHAF2 [mitochondrial matrix]
(R-HSA-9854689)
0.556
3
UniProt:Q9GZU1 MCOLN1
2
MCOLN1 [plasma membrane]
(R-HSA-3211764)
MCOLN1 [endosome membrane]
(R-HSA-917803)
0.556
3
UniProt:P63252 KCNJ2
1
KCNJ2 [plasma membrane]
(R-HSA-975378)
0.556
3
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.556
3
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