Reactome | HIGD1C [mitochondrial inner membrane]

HIGD1C [mitochondrial inner membrane]

Stable Identifier

R-HSA-9865734

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:A8MV81 HIGD1C

Gene Names

HIGD1C, UBIE, UBIE2

Chain

chain:1-97

Reference Genes

BioGPS Gene:613227 HIGD1C

COSMIC (genes):HIGD1C HIGD1C

CTD Gene:613227 HIGD1C

dbSNP Gene:613227 HIGD1C

ENSEMBL:ENSG00000214511 HIGD1C

HGNC:28044 HIGD1C

KEGG:hsa:613227 HIGD1C

Monarch:613227 HIGD1C

NCBI Gene:613227 HIGD1C

OMIM:620803 HIGD1C

UCSC:A8MV81 HIGD1C

Reference Transcript

RefSeq:NM_001109619.1 HIGD1C

Other Identifiers

11742179_at

16751202

3414760

3414761

3414765

613227

A_33_P3252539

GO:0005515

GO:0005739

GO:0007005

GO:0016020

GO:0043226

GO:0065003

GO:0097250

HMNXSV003046059

ILMN_1866621

ILMN_1900301

TC12000400.hg

This entity regulates

Positively

Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)

Inferred To

BcDNA:RH54117 [mitochondrial inner membrane] (Drosophila melanogaster)

Dmel\CG11825 [mitochondrial inner membrane] (Drosophila melanogaster)

Homologues of HIGD1C [mitochondrial inner membrane] (Drosophila melanogaster)

higd1a [mitochondrial inner membrane] (Danio rerio)

higd1a [mitochondrial inner membrane] (Xenopus tropicalis)

HIGD1C [mitochondrial inner membrane] (Bos taurus)

HIGD1C [mitochondrial inner membrane] (Canis familiaris)

HIGD1C [mitochondrial inner membrane] (Gallus gallus)

HIGD1C [mitochondrial inner membrane] (Sus scrofa)

Higd1c [mitochondrial inner membrane] (Mus musculus)

Higd1c [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

ENSEMBL

ENSP00000512274, ENST00000398455, ENST00000695931, ENSP00000381473, ENSG00000214511

OpenTargets

ENSG00000214511

GeneCards

HIGD1C

HPA

ENSG00000214511-HIGD1C

PRO

A8MV81

Pharos - Targets

A8MV81

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N0V3 RBFA			0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:Q15560 TCEA2			0.556	3
UniProt:Q96E29 MTERF3	4	Ub-MTERFD1 [mitochondrial outer membrane] (R-HSA-9843333) K48polyUb-MTERFD1 [mitochondrial outer membrane] (R-HSA-5205630) K63polyUb-MTERFD1 [mitochondrial outer membrane] (R-HSA-9834044) p-S65-Ub:MTERFD1 [mitochondrial outer membrane] (R-HSA-9843337)	0.556	3
UniProt:Q17RD7 SYT16			0.556	3
UniProt:Q96AL5 Q96AL5			0.556	3
UniProt:Q9UHD4 CIDEB			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q9NUH8 TM14B			0.556	3
UniProt:Q9UHQ9 CYB5R1	3	CYB5R1 [plasma membrane] (R-HSA-8848888) CYB5R1 [platelet alpha granule membrane] (R-HSA-8848891) CYB5R1 [endoplasmic reticulum membrane] (R-HSA-6806847)	0.556	3
UniProt:P02654 APOC1	1	APOC1 [extracellular region] (R-HSA-8855541)	0.556	3
UniProt:Q05329 GAD2	2	PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888582) PXLP-K396-GAD2 [plasma membrane] (R-HSA-936509)	0.556	3
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.556	3

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