Reactome | DGAT2L6 [endoplasmic reticulum membrane]

DGAT2L6 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-8848588

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Diacylglycerol O-acyltransferase 2-like protein 6, DC3, Diacylglycerol O-acyltransferase candidate 3

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
15671038	Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily Turkish, AR, Henneberry, AL, Cromley, D, Padamsee, M, Oelkers, P, Bazzi, H, Christiano, AM, Billheimer, JT, Sturley, SL	J. Biol. Chem.	2005

External Reference Information

External Reference

UniProt:Q6ZPD8 DGAT2L6

Gene Names

DGAT2L6, DC3

Chain

chain:1-337

Reference Genes

BioGPS Gene:347516 DGAT2L6

COSMIC (genes):DGAT2L6 DGAT2L6

CTD Gene:347516 DGAT2L6

dbSNP Gene:347516 DGAT2L6

ENSEMBL:ENSG00000184210 DGAT2L6

HGNC:23250 DGAT2L6

KEGG:hsa:347516 DGAT2L6

Monarch:347516 DGAT2L6

NCBI Gene:347516 DGAT2L6

OMIM:300926 DGAT2L6

UCSC:Q6ZPD8 DGAT2L6

Reference Transcript

RefSeq:NM_198512.3 DGAT2L6

Other Identifiers

11741921_at

17104427

347516

3980483

3980484

3980486

3980487

3980488

3980491

3980492

3980493

3980494

3980495

3980496

3980497

8168098

A_33_P3312686

GO:0004144

GO:0005515

GO:0005783

GO:0005789

GO:0006629

GO:0006640

GO:0008374

GO:0016020

GO:0016740

GO:0016746

GO:0036155

HMNXSV003023178

PH_hs_0033848

TC0X000371.hg

Inferred To

Dmel\CG1941 [endoplasmic reticulum membrane] (Drosophila melanogaster)

dga1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

dgat2 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

mogat3b [endoplasmic reticulum membrane] (Danio rerio)

DGAT2L6 [endoplasmic reticulum membrane] (Bos taurus)

DGAT2L6 [endoplasmic reticulum membrane] (Sus scrofa)

dgat2l6 [endoplasmic reticulum membrane] (Xenopus tropicalis)

DGA1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Dgat2l6 [endoplasmic reticulum membrane] (Mus musculus)

Dgat2l6 [endoplasmic reticulum membrane] (Rattus norvegicus)

Dmel\CG1946 [endoplasmic reticulum membrane] (Drosophila melanogaster)

AWAT1 [endoplasmic reticulum membrane] (Gallus gallus)

Dgat2 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Homologues of DGAT2L6 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_940914.1

OpenTargets

ENSG00000184210

ENSEMBL

ENSG00000184210, ENSP00000328036, ENST00000333026

GeneCards

DGAT2L6

HPA

ENSG00000184210-DGAT2L6

PRO

Q6ZPD8

Pharos - Targets

Q6ZPD8

GlyGen

Q6ZPD8

HMDB Protein

HMDBP07280

Interactors (45)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WV15 T255B			0.556	3
UniProt:P49638 TTPA	1	TTPA [cytosol] (R-HSA-2980979)	0.556	3
UniProt:P49675 STAR	2	STAR [mitochondrial matrix] (R-HSA-9838092) STAR [mitochondrial intermembrane space] (R-HSA-196120)	0.556	3
UniProt:Q96CM8 ACSF2	1	ACSF2 [mitochondrial matrix] (R-HSA-5696005)	0.556	3
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.556	3
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q8TB40 ABHD4	1	ABHD4 [endoplasmic reticulum membrane] (R-HSA-5694582)	0.556	3
UniProt:Q96AL5 Q96AL5			0.556	3
UniProt:Q5VYK3 ECM29			0.556	3
UniProt:O95219 SNX4			0.556	3
UniProt:Q96AN5 TM143			0.556	3
UniProt:Q9H6H4 REEP4			0.556	3
UniProt:Q00013 MPP1	1	MPP1 [plasma membrane] (R-HSA-420423)	0.556	3
UniProt:Q7Z6M4 MTERF4	1	MTERF4 [mitochondrial matrix] (R-HSA-6793089)	0.556	3
UniProt:Q96GQ5 RUSF1			0.556	3
UniProt:Q8WTS1 ABHD5	2	ABHD5 [lipid droplet] (R-HSA-163485) ABHD5 [cytosol] (R-HSA-163531)	0.556	3
UniProt:Q05329 GAD2	2	PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888582) PXLP-K396-GAD2 [plasma membrane] (R-HSA-936509)	0.556	3
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.556	3
UniProt:Q6PL24 TMED8			0.556	3
UniProt:Q9ULP0-2 NDRG4			0.556	3
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.556	3
UniProt:Q6PCT2-2 FBXL19			0.556	3
UniProt:Q8IX19 MCEMP1	3	MCEMP1 [tertiary granule membrane] (R-HSA-6800975) MCEMP1 [plasma membrane] (R-HSA-6806288) MCEMP1 [specific granule membrane] (R-HSA-6799637)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:P57086 SCND1			0.556	3
UniProt:Q9H0W8 SMG9	1	SMG9 [cytosol] (R-HSA-927812)	0.556	3
UniProt:Q9Y320 TMX2			0.556	3
UniProt:Q12982 BNIP2	1	BNIP2 [cytosol] (R-HSA-200792)	0.556	3
IntAct:EBI-22589183 CCSB ORF ID			0.556	3
UniProt:Q9NUH8 TM14B			0.556	3
UniProt:Q9HB07 MYG1			0.556	3
UniProt:A0A384ME17 A0A384ME17			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:P50876 RNF144A	1	RNF144A [endosome membrane] (R-HSA-8938771)	0.556	3
UniProt:Q9NR28 DIABLO	2	DIABLO [cytosol] (R-HSA-114298) DIABLO [mitochondrial intermembrane space] (R-HSA-64637)	0.556	3
UniProt:Q9H115 NAPB	1	NAPB [cytosol] (R-HSA-5688553)	0.556	3
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.556	3
UniProt:Q8WY91 THAP4			0.556	3
UniProt:Q9UKF7-2 PITPNC1			0.556	3
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:Q9H5X1 CIA2A			0.556	3
UniProt:Q9Y4P8-4 WIPI2			0.556	3

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