Reactome | GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

GAD2

Stable Identifier

R-HSA-888582

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

Synonyms

Glutamate decarboxylase 2, DCE2_HUMAN, GAD65

Locations in the PathwayBrowser

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Summation

GAD65 or GAD2 is concentrated in the nerve terminal region in the neurons and is involved in the synthesis of GABA which is used as a neurotransmitter.

External Reference Information

External Reference

UniProt:Q05329 GAD2

Gene Names

GAD2, GAD65

Chain

chain:1-585

Reference Genes

BioGPS Gene:2572 GAD2

COSMIC (genes):GAD2 GAD2

CTD Gene:2572 GAD2

dbSNP Gene:2572 GAD2

ENSEMBL:ENSG00000136750 GAD2

HGNC:4093 GAD2

KEGG Gene (Homo sapiens):hsa:2572 GAD2

Monarch:2572 GAD2

NCBI Gene:2572 GAD2

OMIM:138275 GAD2

Reference Transcript

Other Identifiers

11730977_a_at

11730978_a_at

11737613_a_at

16703382

1ES0

206780_at

211264_at

216651_s_at

2572

2OKK

32279_at

32280_at

3239677

3239678

3239679

3239680

3239681

3239682

3239684

3239686

3239687

3239690

3239692

3239693

3239695

3239701

3239712

3239713

3239714

3239721

3239722

3239723

3239725

3239726

3239727

3239728

3239729

3239730

3239731

3239732

3239733

3239734

3239736

44637

78177

7926766

A_14_P107931

A_23_P75008

A_33_P3420530

AAA52513

AAA58491

AAA62367

AAI26328

AAI26330

AAP88040

AY340073

BC126327

BC126329

CAA49554

CAB078177

CCDS7149

CH471072

EAW86102

EAW86103

ENSG00000136750

ENSP00000259271

ENSP00000365437

ENST00000259271

ENST00000376261

EntrezGene:2572

g182933_3p_at

g4503874_3p_at

GAD2

GAD2-201

GAD2-203

GE58074

GO:0000139

GO:0003674

GO:0003824

GO:0004351

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006520

GO:0006540

GO:0007267

GO:0007268

GO:0008150

GO:0009056

GO:0009058

GO:0016020

GO:0016595

GO:0016829

GO:0016831

GO:0019752

GO:0030054

GO:0030170

GO:0030424

GO:0030672

GO:0031225

GO:0031410

GO:0042136

GO:0042493

GO:0042734

GO:0043167

GO:0043226

GO:0044281

GO:0045202

GO:0046982

GO:0048471

GO:0060077

GO:0061202

HGNC:4093

HPA044637

Hs.170808.2.S1_3p_a_at

Hs2.170808.3.S1_3p_s_at

ILMN_1728301

IPR002129

IPR015421

IPR015422

IPR015424

IPR021115

M70435

M74826

M74826_at

M81882

M81882_at

MIM:138275

NM_000818

NM_001134366

NP_000809

NP_001127838

PF00282

PH_hs_0023154

Q5VZ29

Q5VZ30

Q5VZ31

TC10000180.hg

uc001isp.3

uc001isq.3

UPI0000033835

X69936

Participant Of

output

GAD2 gene expression is stimulated by MECP2

hasComponent

Other forms of this molecule

GAD2 [plasma membrane]

Inferred To

Homologues of GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Caenorhabditis elegans)

Homologues of GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Gallus gallus)

GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Bos taurus)

GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Caenorhabditis elegans)

GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Canis familiaris)

GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Danio rerio)

GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Drosophila melanogaster)

GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Gallus gallus)

GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Rattus norvegicus)

GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Sus scrofa)

GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Taeniopygia guttata)

GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Xenopus tropicalis)

Gad2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Mus musculus)

Cross References

RefSeq

NP_000809.1, NP_001127838.1

GeneCards

Q05329

PRO

Q05329

BRENDA (Homo sapiens)

4.1.1.15

Orphanet

27039

HMDB Protein

HMDBP00702

PDB

2OKK, 1ES0

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96B96 TM159			0.696	5
UniProt:Q969L2 MAL2			0.696	5
UniProt:Q15041 AR6P1			0.696	5
UniProt:Q96DZ9 CKLF5			0.556	3
UniProt:Q6RW13 AGTRAP	2	p-AGTRAP-BRAF fusion [cytosol] (R-HSA-6802511) AGTRAP-BRAF fusion [cytosol] (R-HSA-6802262)	0.556	3
UniProt:A8MV81 HIG1C			0.488	2
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.488	2
UniProt:A0PK00 T120B			0.488	2
UniProt:Q6PIF2 SYCE2	1	SYCE2 [nucleoplasm] (R-HSA-912451)	0.488	2
UniProt:Q8WZ55 BSND	1	BSND [plasma membrane] (R-HSA-2854996)	0.488	2
UniProt:Q96GL9 F163A			0.488	2
UniProt:Q8N9I5 FADS6			0.488	2
UniProt:Q06432 CACNG1	1	CACNG1 [plasma membrane] (R-HSA-2671921)	0.488	2
UniProt:Q9NZD8 SPG21			0.488	2
UniProt:Q9NRY5 FAM114A2	2	p-FAM114A2-BRAF fusion [cytosol] (R-HSA-6802525) FAM114A2-BRAF fusion [cytosol] (R-HSA-6802321)	0.488	2
UniProt:Q96IW7 SEC22A	3	SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.488	2
UniProt:O15126 SCAMP1	2	SCAMP1 [specific granule membrane] (R-HSA-6806140) SCAMP1 [plasma membrane] (R-HSA-6806161)	0.488	2
UniProt:Q9NS64 RPRM			0.488	2
UniProt:Q5EB52 MEST			0.488	2
UniProt:Q9BUN8 DERL1	1	DERL1 [endoplasmic reticulum membrane] (R-HSA-6781898)	0.488	2
UniProt:Q8IZV5 RDH10	1	RDH10 [endoplasmic reticulum membrane] (R-HSA-2454090)	0.488	2
UniProt:P62805 HIST1H4A	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.488	2
UniProt:Q6RW13-2 AGTRAP			0.488	2
UniProt:Q9UBN6 TNFRSF10D	1	TNFRSF10D [plasma membrane] (R-HSA-5633374)	0.488	2
UniProt:Q3SXY8 ARL13B	1	ARL13B [cilium] (R-HSA-5618181)	0.488	2
UniProt:O60906 SMPD2	1	SMPD2 [plasma membrane] (R-HSA-194337)	0.488	2
UniProt:Q9HC36 MRM3	1	RNMTL1 [mitochondrial matrix] (R-HSA-6793067)	0.488	2
UniProt:Q8N8Q1 C56D1			0.488	2
UniProt:Q6ZWK4 RHEX			0.488	2
UniProt:P55327-2 TPD52			0.488	2
UniProt:O43761 SNG3			0.488	2
UniProt:Q6E0U4 DMKN			0.488	2
UniProt:O60664 PLIN3	2	PLIN3 [cytosol] (R-HSA-6814628) PLIN3 [transport vesicle] (R-HSA-6813900)	0.488	2
UniProt:Q5BJH2-2 TMEM128			0.488	2
UniProt:Q96AL5 Q96AL5			0.488	2
UniProt:Q7Z7G2 CPLX4			0.488	2
UniProt:Q8WTS1 ABHD5	2	ABHD5 [lipid droplet] (R-HSA-163485) ABHD5 [cytosol] (R-HSA-163531)	0.488	2
UniProt:Q86UF1 TSPAN33	2	TSPAN33 [endoplasmic reticulum lumen] (R-HSA-9010054) TSPAN33 [plasma membrane] (R-HSA-9010024)	0.488	2
UniProt:Q8N3Y7 SDR16C5	1	RDHE2 [endoplasmic reticulum membrane] (R-HSA-5621649)	0.488	2
UniProt:Q9H400 LIME1			0.488	2
UniProt:Q96DZ9-2 CMTM5			0.488	2