PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

Stable Identifier
R-HSA-888582
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
Synonyms
Glutamate decarboxylase 2, DCE2_HUMAN, GAD65
Locations in the PathwayBrowser
Expand all
General

GAD65 or GAD2 is concentrated in the nerve terminal region in the neurons and is involved in the synthesis of GABA which is used as a neurotransmitter.

External Reference Information
External Reference
UniProt:Q05329 GAD2
Gene Names
GAD2, GAD65
Chain
chain:1-585
Reference Genes
BioGPS Gene:2572 GAD2
COSMIC (genes):GAD2 GAD2
CTD Gene:2572 GAD2
dbSNP Gene:2572 GAD2
ENSEMBL:ENSG00000136750 GAD2
HGNC:4093 GAD2
KEGG Gene (Homo sapiens):2572 GAD2
Monarch:2572 GAD2
NCBI Gene:2572 GAD2
OMIM:138275 GAD2
Reference Transcript
Other Identifiers
11730977_a_at
11730978_a_at
11737613_a_at
16703382
1ES0
206780_at
211264_at
216651_s_at
2572
2OKK
32279_at
32280_at
3239678
3239679
3239680
3239681
3239682
3239684
3239686
3239687
3239690
3239692
3239693
3239695
3239701
3239712
3239713
3239714
3239721
3239722
3239723
3239725
3239726
3239727
3239728
3239729
3239730
3239731
3239732
3239733
3239734
3239736
44637
78177
7926766
A0A3B3IU09
A_14_P107931
A_23_P75008
A_33_P3420530
AAA52513
AAA58491
AAA62367
AAI26328
AAI26330
AAP88040
AY340073
BC126327
BC126329
CAA49554
CAB078177
CCDS7149
CH471072
EAW86102
EAW86103
ENSG00000136750
ENSP00000259271
ENSP00000365437
ENST00000259271
ENST00000259271.7
ENST00000376261
ENST00000376261.7
EntrezGene:2572
EntrezGene:GAD2
g182933_3p_at
g4503874_3p_at
GAD2
GAD2-201
GAD2-203
GE58074
GO:0000139
GO:0003674
GO:0003824
GO:0004351
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0006520
GO:0006540
GO:0006810
GO:0007267
GO:0007268
GO:0007269
GO:0008150
GO:0009056
GO:0009058
GO:0016020
GO:0016595
GO:0016829
GO:0016831
GO:0019752
GO:0030054
GO:0030170
GO:0030424
GO:0030672
GO:0031225
GO:0031410
GO:0042136
GO:0042493
GO:0042734
GO:0043167
GO:0043226
GO:0044281
GO:0045202
GO:0046982
GO:0048471
GO:0060077
GO:0061202
HGNC:4093
HPA044637
Hs.170808.2.S1_3p_a_at
Hs2.170808.3.S1_3p_s_at
ILMN_1728301
IPR002129
IPR015421
IPR015424
IPR021115
M70435
M74826
M74826_at
M81882
M81882_at
MIM:138275
NM_000818
NM_001134366
NP_000809
NP_001127838
PF00282
PH_hs_0023154
Q5VZ30
Q5VZ31
TC10000180.hg
UPI0000033835
X69936
Participant Of
output
hasComponent
Other forms of this molecule
PXLP-K396-GAD2 [plasma membrane]
Inferred To
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Bos taurus)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Caenorhabditis elegans)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Danio rerio)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Drosophila melanogaster)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Gallus gallus)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Mus musculus)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Rattus norvegicus)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Sus scrofa)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Xenopus tropicalis)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 396
Coordinate
396
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
RefSeq
OpenTargets
IntEnz
GeneCards
PRO
Orphanet
HMDB Protein
PDB
Interactors (41)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q96B96 TM159      0.696 5
 UniProt:Q969L2 MAL2      0.696 5
 UniProt:Q15041 AR6P1      0.696 5
 UniProt:Q96DZ9 CKLF5      0.556 3
 UniProt:Q6RW13 AGTRAP  2 0.556 3
 UniProt:A8MV81 HIG1C      0.488 2
 UniProt:Q6ZPD8 DGAT2L6  1 0.488 2
 UniProt:A0PK00 T120B      0.488 2
 UniProt:Q8WZ55 BSND  1 0.488 2
 UniProt:Q96GL9 F163A      0.488 2
 UniProt:Q8N9I5 FADS6      0.488 2
 UniProt:Q06432 CACNG1  1 0.488 2
 UniProt:Q9NZD8 SPG21      0.488 2
 UniProt:Q9NRY5 FAM114A2  2 0.488 2
 UniProt:Q96IW7 SEC22A  3 0.488 2
 UniProt:O15126 SCAMP1  2 0.488 2
 UniProt:Q9NS64 RPRM      0.488 2
 UniProt:Q5EB52 MEST      0.488 2
 UniProt:Q9BUN8 DERL1  1 0.488 2
 UniProt:Q8IZV5 RDH10  1 0.488 2
 UniProt:Q6RW13-2 AGTRAP      0.488 2
 UniProt:Q96DZ9-2 CMTM5      0.488 2
 UniProt:Q9H400 LIME1      0.488 2
 UniProt:Q8N3Y7 SDR16C5  1 0.488 2
 UniProt:O60664 PLIN3  7 0.488 2
 UniProt:O60906 SMPD2  1 0.488 2
 UniProt:P62805 H4C1  19 0.488 2
 UniProt:Q8WTS1 ABHD5  2 0.488 2
 UniProt:Q9UBN6 TNFRSF10D  1 0.488 2
 UniProt:Q9HC36 MRM3  1 0.488 2
 UniProt:Q3SXY8 ARL13B  7 0.488 2
 UniProt:Q6PIF2 SYCE2  1 0.488 2
 UniProt:Q8N8Q1 C56D1      0.488 2
 UniProt:Q6ZWK4 RHEX      0.488 2
 UniProt:P55327-2 TPD52      0.488 2
 UniProt:O43761 SNG3      0.488 2
 UniProt:Q6E0U4 DMKN      0.488 2
 UniProt:Q5BJH2-2 TMEM128      0.488 2
 UniProt:Q96AL5 Q96AL5      0.488 2
 UniProt:Q7Z7G2 CPLX4      0.488 2
 UniProt:Q86UF1 TSPAN33  2 0.488 2