Reactome | PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

Stable Identifier

R-HSA-888582

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

Synonyms

Glutamate decarboxylase 2, DCE2_HUMAN, GAD65

Locations in the PathwayBrowser

Expand all

General

GAD65 or GAD2 is concentrated in the nerve terminal region in the neurons and is involved in the synthesis of GABA which is used as a neurotransmitter.

External Reference Information

External Reference

UniProt:Q05329 GAD2

Gene Names

GAD2, GAD65

Chain

chain:1-585

Reference Genes

BioGPS Gene:2572 GAD2

COSMIC (genes):GAD2 GAD2

CTD Gene:2572 GAD2

dbSNP Gene:2572 GAD2

ENSEMBL:ENSG00000136750 GAD2

HGNC:4093 GAD2

KEGG:hsa:2572 GAD2

Monarch:2572 GAD2

NCBI Gene:2572 GAD2

OMIM:138275 GAD2

UCSC:Q05329 GAD2

Reference Transcript

Other Identifiers

11730977_a_at

11730978_a_at

11737613_a_at

16703382

206780_PM_at

206780_at

211264_PM_at

211264_at

216651_PM_s_at

216651_s_at

2572

32279_at

32280_at

3239678

3239679

3239680

3239681

3239682

3239683

3239684

3239686

3239687

3239688

3239690

3239691

3239692

3239693

3239694

3239695

3239701

3239712

3239713

3239714

3239721

3239722

3239723

3239725

3239726

3239727

3239728

3239729

3239730

3239731

3239732

3239733

3239734

3239736

7926766

A_14_P107931

A_23_P75008

A_33_P3332369

A_33_P3420530

GE58074

GO:0000139

GO:0003824

GO:0004351

GO:0005515

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006520

GO:0006540

GO:0006950

GO:0007268

GO:0009410

GO:0009449

GO:0016595

GO:0016829

GO:0016830

GO:0016831

GO:0019752

GO:0023052

GO:0030170

GO:0030424

GO:0030672

GO:0031410

GO:0031982

GO:0032570

GO:0042220

GO:0042734

GO:0042995

GO:0043025

GO:0043226

GO:0044877

GO:0045202

GO:0048471

GO:0060077

GO:0061202

GO:0061771

GO:0071456

GO:0071548

GO:0098793

GO:0098982

GO:1990416

HMNXSV003017356

HMNXSV003056230

Hs.170808.2.S1_3p_a_at

Hs2.170808.3.S1_3p_at

Hs2.170808.3.S1_3p_s_at

ILMN_1728301

M74826_at

M81882_at

PH_hs_0023154

TC10000180.hg

g182933_3p_at

g4503874_3p_at

Participates

as an output of

GAD2 gene expression is stimulated by MECP2 (Homo sapiens)

as a component of

Other forms of this molecule

PXLP-K396-GAD2 [plasma membrane]

Inferred To

gad2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Xenopus tropicalis)

PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Canis familiaris)

PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Drosophila melanogaster)

PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Gallus gallus)

PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Mus musculus)

PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Rattus norvegicus)

PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Sus scrofa)

GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Bos taurus)

GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Sus scrofa)

unc-25 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Caenorhabditis elegans)

Homologues of PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Sus scrofa)

Modified Residues

Name

N6-pyridoxal phosphate-L-lysine at 396

Coordinate

396

PsiMod Name

N6-pyridoxal phosphate-L-lysine [MOD:00128]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.

Cross References

RefSeq

NP_000809.1, NP_001127838.1

Guide to Pharmacology - Targets

1273

OpenTargets

ENSG00000136750

ENSEMBL

ENST00000376261, ENST00000259271, ENSP00000365437, ENSG00000136750, ENSP00000259271

IntEnz

4.1.1.15

GeneCards

GAD2

HPA

ENSG00000136750-GAD2

PRO

Q05329

Pharos - Targets

Q05329

HMDB Protein

HMDBP00702

PDB

1ES0, 2OKK

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96B96 LDAF1			0.718	6
UniProt:Q969L2 MAL2			0.718	6
UniProt:Q15041 AR6P1			0.718	6
UniProt:O60664 PLIN3	7	p-PLIN3 [lysosomal lumen] (R-HSA-9639396) p-PLIN3 [cytosol] (R-HSA-9613664) p-PLIN3 [lipid droplet] (R-HSA-9613539) PLIN3 [lipid droplet] (R-HSA-9613337) p-PLIN3 [late endosome lumen] (R-HSA-9639393) PLIN3 [cytosol] (R-HSA-6814628) PLIN3 [transport vesicle] (R-HSA-6813900)	0.556	3
UniProt:Q8WTS1 ABHD5	2	ABHD5 [lipid droplet] (R-HSA-163485) ABHD5 [cytosol] (R-HSA-163531)	0.556	3
UniProt:Q9UBN6 TNFRSF10D	1	TNFRSF10D [plasma membrane] (R-HSA-5633374)	0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:O60906 SMPD2	1	SMPD2 [plasma membrane] (R-HSA-194337)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:P55056 APOC4	1	APOC4 [extracellular region] (R-HSA-5215930)	0.556	3
UniProt:Q6ZWK4 RHEX			0.556	3
UniProt:Q8N8Q1 C56D1			0.556	3
UniProt:O43761 SNG3			0.556	3
UniProt:Q9HC36 MRM3	1	RNMTL1 [mitochondrial matrix] (R-HSA-6793067)	0.556	3
UniProt:Q6E0U4 DMKN	1	DMKN [secretory granule lumen] (R-HSA-9839542)	0.556	3
UniProt:Q5BJH2-2 TMEM128			0.556	3
UniProt:Q96DZ9 CKLF5			0.556	3
UniProt:Q96AL5 Q96AL5			0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q5T9G4-2 ARMC12			0.556	3
UniProt:Q86UF1 TSPAN33	2	TSPAN33 [plasma membrane] (R-HSA-9010024) TSPAN33 [endoplasmic reticulum lumen] (R-HSA-9010054)	0.556	3
UniProt:Q8N3Y7 SDR16C5	1	RDHE2 [endoplasmic reticulum membrane] (R-HSA-5621649)	0.556	3
UniProt:Q9H400 LIME1			0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q8IZV5 RDH10	1	RDH10 [endoplasmic reticulum membrane] (R-HSA-2454090)	0.556	3
UniProt:Q9BUN8 DERL1	1	DERL1 [endoplasmic reticulum membrane] (R-HSA-6781898)	0.556	3
UniProt:Q5EB52 MEST			0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562)	0.556	3
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:Q9NRY5 FAM114A2	2	FAM114A2(1-327)-BRAF(439-766) fusion [cytosol] (R-HSA-6802321) FAM114A2(1-327)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802525)	0.556	3
UniProt:Q96Q80 DERL3	1	DERL3 [endoplasmic reticulum membrane] (R-HSA-8866516)	0.556	3
UniProt:Q06432 CCG1			0.556	3
UniProt:Q8N9I5 FADS6			0.556	3
UniProt:Q96GL9 F163A			0.556	3
UniProt:Q6PIF2 SYCE2	1	SYCE2 [nucleoplasm] (R-HSA-912451)	0.556	3
UniProt:Q8WZ55 BSND	1	BSND [plasma membrane] (R-HSA-2854996)	0.556	3
UniProt:A0PK00 T120B			0.556	3
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511) AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262)	0.556	3
UniProt:A8MV81 HIGD1C	1	HIGD1C [mitochondrial inner membrane] (R-HSA-9865734)	0.556	3

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