Reactome | AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol]

AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol]

Stable Identifier

R-HSA-6802511

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
20526349	Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma Shankar, S, Siddiqui, J, Kuefer, R, Chen, YB, Greenson, JK, Lafargue, CJ, Ramnarayanan, K, Han, B, Palanisamy, N, Demichelis, F, Esgueva, R, Dhanasekaran, SM, Giordano, TJ, Fullen, DR, Pflueger, D, Moeller, P, Rubin, MA, Maher, CA, Cao, Q, Cao, X, Ateeq, B, Banerjee, S, Bismar, TA, Tomlins, SA, Varambally, S, Kumar-Sinha, C, Chinnaiyan, AM, Johnson, TM, Suleman, K, Tan, P, Kalyana-Sundaram, S	Nat. Med.	2010

External Reference Information

External Reference

UniProt:Q6RW13 AGTRAP

Gene Names

AGTRAP, ATRAP

Chain

chain:1-159

Reference Genes

BioGPS Gene:57085 AGTRAP

COSMIC (genes):AGTRAP AGTRAP

CTD Gene:57085 AGTRAP

dbSNP Gene:57085 AGTRAP

ENSEMBL:ENSG00000177674.16 AGTRAP

HGNC:13539 AGTRAP

KEGG Gene (Homo sapiens):57085 AGTRAP

Monarch:57085 AGTRAP

NCBI Gene:57085 AGTRAP

OMIM:608729 AGTRAP

UCSC:Q6RW13 AGTRAP

Reference Transcript

Other Identifiers

0001170053

11727478_a_at

11753685_a_at

11753686_s_at

11753687_x_at

1555736_PM_a_at

1555736_a_at

16659054

225059_PM_at

225059_at

2320412

2320413

2320417

2320420

2320421

2320423

2320424

2320425

56548_at

57085

7897745

GE62121

GE82526

GO:0000139

GO:0001666

GO:0003013

GO:0004945

GO:0005515

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0005938

GO:0008217

GO:0016020

GO:0016021

GO:0023052

GO:0030659

GO:0031410

GO:0038166

GO:0042802

GO:0043226

GO:0043231

GO:0060089

Hs.12854.0.S2_3p_at

Hs2.12854.2.S1_3p_s_at

ILMN_1802458

ILMN_2307656

PH_hs_0001230

TC01000147.hg

Participates

as a component of

p-AGTRAP-BRAF fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

AGTRAP(1-159)-BRAF(288-545) fusion [cytosol]

Modified Residues

Name

Insertion of residues 288 to 545 at 160 from UniProt:P15056 BRAF

Coordinate

160

Name

O-phospho-L-serine at 445

Coordinate

445

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 729

Coordinate

729

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 599

Coordinate

599

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 602

Coordinate

602

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
gastric adenocarcinoma	DOID:3717	adenocarcinoma of stomach (disorder), stomach adenocarcinoma
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_001035287.1, NP_001035285.1, NP_001035284.1, NP_001035286.1, NP_065083.3

OpenTargets

ENSG00000177674

GeneCards

Q6RW13

HPA

ENSG00000177674-AGTRAP

Ensembl

ENST00000452018, ENST00000400895, ENST00000376637, ENST00000314340, ENSP00000408505, ENST00000376629, ENSP00000319713, ENSP00000383688, ENSP00000365824, ENSP00000365816, ENSG00000177674

PRO

Q6RW13

Pharos - Targets

Q6RW13

HMDB Protein

HMDBP10883

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.666	4
UniProt:Q96CM8 ACSF2	1	ACSF2 [mitochondrial matrix] (R-HSA-5696005)	0.666	4
UniProt:Q96PE7 MCEE	1	MCEE [mitochondrial matrix] (R-HSA-71012)	0.666	4
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.666	4
UniProt:P09429 HMGB1	5	HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221) HMGB1 [extracellular region] (R-HSA-879382)	0.556	3
UniProt:Q6IN84 MRM1	1	MRM1 [mitochondrial matrix] (R-HSA-6793088)	0.556	3
UniProt:Q05329 GAD2	2	PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888582) PXLP-K396-GAD2 [plasma membrane] (R-HSA-936509)	0.556	3
UniProt:Q96E29 MTERF3	2	K48polyUb-MTERFD1 [mitochondrial outer membrane] (R-HSA-5205630) MTERFD1 [mitochondrial outer membrane] (R-HSA-5205688)	0.556	3
UniProt:O95971 CD160	1	CD160 [plasma membrane] (R-HSA-198014)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:P49590 HARS2	1	HARS2 [mitochondrial matrix] (R-HSA-379581)	0.556	3
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.556	3
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.556	3
UniProt:Q9UKL6 PCTP	1	PCTP [cytosol] (R-HSA-5215990)	0.556	3
UniProt:Q99259 GAD1	2	PXLP-K405-GAD1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888580) PXLP-K405-GAD1 [plasma membrane] (R-HSA-947477)	0.556	3
UniProt:Q00059 TFAM	2	TFAM [mitochondrial matrix] (R-HSA-163312) TFAM(1-246) [cytosol] (R-HSA-1592203)	0.556	3