Reactome | AGTRAP(1-159)-BRAF(288-545) fusion [cytosol]

AGTRAP(1-159)-BRAF(288-545) fusion [cytosol]

Stable Identifier

R-HSA-6802262

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
20526349	Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma Shankar, S, Siddiqui, J, Kuefer, R, Chen, YB, Greenson, JK, Lafargue, CJ, Ramnarayanan, K, Han, B, Palanisamy, N, Demichelis, F, Esgueva, R, Dhanasekaran, SM, Giordano, TJ, Fullen, DR, Pflueger, D, Moeller, P, Rubin, MA, Maher, CA, Cao, Q, Cao, X, Ateeq, B, Banerjee, S, Bismar, TA, Tomlins, SA, Varambally, S, Kumar-Sinha, C, Chinnaiyan, AM, Johnson, TM, Suleman, K, Tan, P, Kalyana-Sundaram, S	Nat. Med.	2010

External Reference Information

External Reference

UniProt:Q6RW13 AGTRAP

Gene Names

AGTRAP, ATRAP

Chain

chain:1-159

Reference Genes

BioGPS Gene:57085 AGTRAP

COSMIC (genes):AGTRAP AGTRAP

CTD Gene:57085 AGTRAP

dbSNP Gene:57085 AGTRAP

ENSEMBL:ENSG00000177674 AGTRAP

HGNC:13539 AGTRAP

KEGG:hsa:57085 AGTRAP

Monarch:57085 AGTRAP

NCBI Gene:57085 AGTRAP

OMIM:608729 AGTRAP

UCSC:Q6RW13 AGTRAP

Reference Transcript

Participates

as a component of

AGTRAP-BRAF fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol]

Modified Residues

Name

Insertion of residues 288 to 545 at 160 from UniProt:P15056 BRAF

Coordinate

160

Name

O-phospho-L-serine at 446

Coordinate

446

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 729

Coordinate

729

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
gastric adenocarcinoma	DOID:3717	adenocarcinoma of stomach (disorder), stomach adenocarcinoma
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

OpenTargets

ENSG00000177674

ENSEMBL

ENSP00000383688, ENST00000314340, ENSG00000177674, ENSP00000319713, ENSP00000408505, ENSP00000365824, ENST00000400895, ENST00000376629, ENST00000452018, ENST00000376637, ENSP00000365816

HPA

ENSG00000177674-AGTRAP

GeneCards

AGTRAP

PRO

Q6RW13

Pharos - Targets

Q6RW13

HMDB Protein

HMDBP10883

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CM8 ACSF2	1	ACSF2 [mitochondrial matrix] (R-HSA-5696005)	0.666	4
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.666	4
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.666	4
UniProt:Q96PE7 MCEE	1	MCEE [mitochondrial matrix] (R-HSA-71012)	0.666	4
UniProt:Q99259 GAD1	2	PXLP-K405-GAD1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888580) PXLP-K405-GAD1 [plasma membrane] (R-HSA-947477)	0.556	3
UniProt:P49590 HARS2	1	HARS2 [mitochondrial matrix] (R-HSA-379581)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:P39905 GDNF	1	GDNF [extracellular region] (R-HSA-375061)	0.556	3
UniProt:P09429 HMGB1	5	HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HMGB1 [secretory granule lumen] (R-HSA-6803337)	0.556	3
UniProt:Q9UKL6 PCTP	1	PCTP [cytosol] (R-HSA-5215990)	0.556	3
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.556	3
UniProt:Q00059 TFAM	3	TFAM [mitochondrial matrix] (R-HSA-163312) TFAM(1-246) [cytosol] (R-HSA-1592203) p-S55,S56,S61,S160-TFAM [mitochondrial matrix] (R-HSA-9838277)	0.556	3
UniProt:O95971 CD160	1	CD160 [plasma membrane] (R-HSA-198014)	0.556	3
UniProt:Q05329 GAD2	2	PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888582) PXLP-K396-GAD2 [plasma membrane] (R-HSA-936509)	0.556	3
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.556	3
UniProt:Q969Z0 TBRG4	1	TBRG4 [mitochondrial matrix] (R-HSA-9837166)	0.556	3
UniProt:Q6IN84 MRM1	1	MRM1 [mitochondrial matrix] (R-HSA-6793088)	0.556	3
UniProt:Q6UWR7 ENPP6	1	ENPP6 [plasma membrane] (R-HSA-6814799)	0.527	2

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