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2xHC-INS(25-54) [extracellular region]
Stable Identifier
R-HSA-74673
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
insulin B chain
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
FOXO1:PPARGC1A,FOXO4 binds PCK1 gene promoter (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Exocytosis of Insulin (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Synthesis, secretion, and deacylation of Ghrelin (Homo sapiens)
Acyl Ghrelin and C-Ghrelin are secreted (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
Activated SRC,LCK,EGFR,INSR [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Autophosphorylation of insulin receptor (Homo sapiens)
Insulin:Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Insulin binds the insulin receptor (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Insulin:Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
Binding of SHC1 to insulin receptor (Homo sapiens)
GRB10:INSR [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Dissociation of p-Y427-SHC1 from insulin receptor (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
IRS activation (Homo sapiens)
Binding of IRS to insulin receptor (Homo sapiens)
GRB10:INSR [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Dissociation of IRS-P from insulin receptor (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Phosphorylation of IRS (Homo sapiens)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Phosphorylation of SHC1 (Homo sapiens)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Signal attenuation (Homo sapiens)
Binding of Grb10 to the insulin receptor (Homo sapiens)
GRB10:INSR [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
Internalisation of the insulin receptor (Homo sapiens)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Insulin [extracellular region] (Homo sapiens)
2xHC-INS(25-54) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01308 INS
Gene Names
INS
Chain
signal peptide:1-24, peptide:25-54, propeptide:57-87, peptide:90-110
Reference Genes
COSMIC (genes):INS INS
dbSNP Gene:3630 INS
ENSEMBL:ENSG00000254647 INS
Participates
as a component of
Insulin [extracellular region] (Homo sapiens)
Other forms of this molecule
6xHC-INS(25-110) [Golgi lumen]
6xHC-INS(25-110) [secretory granule lumen]
2xHC-INS(25-56) [secretory granule lumen]
INS(57-89) [secretory granule lumen]
4xHC-INS(57-110) [secretory granule lumen]
6xHC-INS(25-110) [endoplasmic reticulum lumen]
INS(57-87) [extracellular region]
C Peptide [secretory granule lumen]
4xHC-INS(90-110) [secretory granule lumen]
2xHC-INS(25-54) [secretory granule lumen]
INS(25-110) [endoplasmic reticulum lumen]
Insulin Aspart B Chain [extracellular region]
Insulin Humalog B Chain [extracellular region]
Insulin Glulisine B Chain [extracellular region]
2xHC-Myri-INS(25-53) [extracellular region]
Insulin Glargine A Chain [extracellular region]
Insulin Glargine B Chain [extracellular region]
4xHC-INS(90-110) [extracellular region]
INS(25-54) [endosome lumen]
INS(90-110) [endosome lumen]
6xHC-INS(25-110) [endoplasmic reticulum-Golgi intermediate compartment membrane]
6xHC-INS(25-110) [transport vesicle]
6xHC-INS(25-110) [Golgi membrane]
Inferred To
Ins1 [extracellular region]
(Mus musculus)
Ins1 [extracellular region]
(Rattus norvegicus)
INS [extracellular region]
(Bos taurus)
INS [extracellular region]
(Canis familiaris)
INS [extracellular region]
(Gallus gallus)
INS [extracellular region]
(Sus scrofa)
ins [extracellular region]
(Danio rerio)
Ghost homologue of 2xHC-INS(25-54) [extracellular region]
(Xenopus tropicalis)
Modified Residues
Name
Inter-chain Crosslink via L-cystine (cross-link) at 31 and 96
Coordinate
31
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Inter-chain Crosslink via L-cystine (cross-link) at 43 and 109
Coordinate
43
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01308 INS
20
6xHC-INS(25-110) [Golgi lumen]
(R-HSA-264890)
6xHC-INS(25-110) [secretory granule lumen]
(R-HSA-264984)
2xHC-INS(25-56) [secretory granule lumen]
(R-HSA-9023201)
INS(57-89) [secretory granule lumen]
(R-HSA-9023172)
4xHC-INS(57-110) [secretory granule lumen]
(R-HSA-9023174)
6xHC-INS(25-110) [endoplasmic reticulum lumen]
(R-HSA-265075)
INS(57-87) [extracellular region]
(R-HSA-265157)
C Peptide [secretory granule lumen]
(R-HSA-265011)
4xHC-INS(90-110) [secretory granule lumen]
(R-HSA-264971)
2xHC-INS(25-54) [secretory granule lumen]
(R-HSA-264902)
INS(25-110) [endoplasmic reticulum lumen]
(R-HSA-264893)
Insulin Aspart B Chain [extracellular region]
(R-HSA-429393)
Insulin Humalog B Chain [extracellular region]
(R-HSA-429397)
Insulin Glulisine B Chain [extracellular region]
(R-HSA-429465)
2xHC-Myri-INS(25-53) [extracellular region]
(R-HSA-429343)
Insulin Glargine A Chain [extracellular region]
(R-HSA-429369)
Insulin Glargine B Chain [extracellular region]
(R-HSA-429347)
2xHC-INS(25-54) [extracellular region]
(R-HSA-74673)
4xHC-INS(90-110) [extracellular region]
(R-HSA-74672)
INS(25-54) [endosome lumen]
(R-HSA-141723)
0.971
21
UniProt:P06213-2 INSR
0.697
6
UniProt:P14735-1 IDE
0.618
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q8IUG1 KRTAP1-3
1
KRTAP1-3 [cytosol]
(R-HSA-6809866)
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
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